Chemical Name: 1,2,4,5-Benzenetetramine tetrahydrochloride
Biological Activity Selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. Prevents FAK autophosphorylation at Y397 (IC50 = 1 μM), promotes cell detachment and inhibits cell adhesion in vitro. Exhibits antiproliferative activity in a variety of human tumor cell lines in vitro and in breast cancer cells in vivo.
Soluble to 50 mM in water and to 75 mM in DMSO
Desiccate at RT
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