FAK Inhibitor 14
Chemical Name: 1,2,4,5-Benzenetetramine tetrahydrochloride
Biological ActivitySelective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. Prevents FAK autophosphorylation at Y397 (IC50 = 1 μM), promotes cell detachment and inhibits cell adhesion in vitro. Exhibits antiproliferative activity in a variety of human tumor cell lines in vitro and in breast cancer cells in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the Y397 site of focal adhesion kinase decreases tumour growth.
Golubovskaya et al.
A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.
Hochwald et al.
Cell Cycle, 2009;8:2435
Citations for FAK Inhibitor 14
The citations listed below are publications that use Tocris products. Selected citations for FAK Inhibitor 14 include:
19 Citations: Showing 1 - 10
Fibroblast activation protein-α promotes the growth and migration of lung cancer cells via the PI3K and sonic hedgehog pathways.
Authors: Jia Et al.
Int J Mol Med 2018;41:275
Matrix stiffness modulates infection of endothelial cells by Listeria monocytogenes via expression of cell surface vimentin.
Authors: Bastounis Et al.
Mol Biol Cell 2018;29:1571
Plectin protects podocytes from adriamycin-induced apoptosis and F-actin cytoskeletal disruption through the integrin α6β4/FAK/p38 MAPK pathway.
Authors: Ni Et al.
J Cell Mol Med 2018;22:5450
Netrin-1 suppresses the MEK/ERK pathway and ITGB4 in pancreatic cancer.
Authors: An Et al.
Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
Cell Communication and Signaling 2016;14:32
Endothelial Cells Use a Formin-Dependent Phagocytosis-Like Process to Internalize the Bacterium Listeria monocytogenes.
Authors: Rengarajan Et al.
PLoS One 2016;12:e1005603
Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer.
Authors: Thakur Et al.
Sci Rep 2015;5:10194
Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells.
Authors: Webber Et al.
RECK-Mediated β1-Integrin Regulation by TGF-β1 Is Critical for Wound Contraction in Mice.
Authors: Gutiérrez Et al.
J Neurosci 2015;10:e0135005
Palladin mediates stiffness-induced fibroblast activation in the tumor microenvironment.
Authors: McLane and Ligon
Biophys J 2015;109:249
Astroglial-derived periostin promotes axonal regeneration after spinal cord injury.
Authors: Shih Et al.
Auton Neurosci 2014;34:2438
OE and tamox. induce cell migration through GPR30 and activation of focal adhesion kinase (FAK) in endometrial cancers with low or without nuclear estrogen receptor α (ERα).
Authors: Tsai Et al.
PLoS One 2013;8:e72999
ERBB4 confers metastatic capacity in Ewing sarcoma.
Authors: Mendoza-Naranjo Et al.
EMBO Mol Med 2013;5:1019
Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis.
Authors: Wiel Et al.
Cell Death Dis 2013;4:e855
CB1 cannabinoid receptors couple to focal adhesion kinase to control Ins release.
Authors: Malenczyk Et al.
J Biol Chem 2013;288:32685
Pathogenic NPHP5 mutations impair protein interaction with Cep290, a prerequisite for ciliogenesis.
Authors: Barbelanne Et al.
Hum Mol Genet 2013;22:2482
Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression.
Authors: Keasey Et al.
Cell Commun Signal 2013;11:35
Inhibitors of Src and focal adhesion kinase promote endocrine specification: impact on the derivation of β-cells from human pluripotent stem cells.
Authors: Afrikanova Et al.
J Biol Chem 2011;286:36042
GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation.
Authors: Tu Et al.
J Neurosci 2010;30:749
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