Selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. Prevents FAK autophosphorylation at Y397 (IC50
= 1 μ
M), promotes cell detachment and inhibits cell adhesion in vitro
. Exhibits antiproliferative activity in a variety of human tumor cell lines in vitro
and in breast cancer cells in vivo
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A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the Y397 site of focal adhesion kinase decreases tumour growth.
Golubovskaya et al.
A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.
Hochwald et al.
Cell Cycle, 2009;8:2435
The citations listed below are publications that use Tocris products. Selected citations for FAK Inhibitor 14 include:
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