FAK Inhibitor 14

  ( 15 citations )    
Product Datasheet
Catalog Number:3414
Alternate Names:Y15, NSC 677249
Chemical Name:1,2,4,5-Benzenetetramine tetrahydrochloride
Product Details
Citations (15)
Reviews
Biological Activity
Selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. Prevents FAK autophosphorylation at Y397 (IC50 = 1 μM), promotes cell detachment and inhibits cell adhesion in vitro. Exhibits antiproliferative activity in a variety of human tumor cell lines in vitro and in breast cancer cells in vivo.
Technical Data
  • M.Wt:
    284.01
  • Formula:
    C6H10N4.4HCl
  • Solubility:
    Soluble to 50 mM in water and to 75 mM in DMSO
  • Storage:
    Desiccate at RT
  • CAS No:
    4506-66-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for FAK Inhibitor 14 include:

15 Citations: Showing 1 - 10
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  1. Netrin-1 suppresses the MEK/ERK pathway and ITGB4 in pancreatic cancer.
    Authors: An Et al.
    Oncotarget  2016;7:24719
  2. Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
    Authors: Visavadiya
    Cell Communication and Signaling  2016;14:32
  3. Endothelial Cells Use a Formin-Dependent Phagocytosis-Like Process to Internalize the Bacterium Listeria monocytogenes.
    Authors: Rengarajan Et al.
    PLoS One  2016;12:e1005603
  4. Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer.
    Authors: Thakur Et al.
    Sci Rep  2015;5:10194
  5. Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells.
    Authors: Webber Et al.
    Oncoscience  2015;2:765
  6. RECK-Mediated β1-Integrin Regulation by TGF-β1 Is Critical for Wound Contraction in Mice.
    Authors: Gutiérrez Et al.
    J Neurosci  2015;10:e0135005
  7. Palladin mediates stiffness-induced fibroblast activation in the tumor microenvironment.
    Authors: McLane and Ligon
    Biophys J  2015;109:249
  8. Astroglial-derived periostin promotes axonal regeneration after spinal cord injury.
    Authors: Shih Et al.
    Auton Neurosci  2014;34:2438
  9. Estradiol and tamoxifen induce cell migration through GPR30 and activation of focal adhesion kinase (FAK) in endometrial cancers with low or without nuclear estrogen receptor α (ERα).
    Authors: Tsai Et al.
    PLoS One  2013;8:e72999
  10. ERBB4 confers metastatic capacity in Ewing sarcoma.
    Authors: Mendoza-Naranjo Et al.
    EMBO Mol Med  2013;5:1019
  11. Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis.
    Authors: Wiel Et al.
    Cell Death Dis  2013;4:e855
  12. CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release.
    Authors: Malenczyk Et al.
    J Biol Chem  2013;288:32685
  13. Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression.
    Authors: Keasey Et al.
    Cell Commun Signal  2013;11:35
  14. Inhibitors of Src and focal adhesion kinase promote endocrine specification: impact on the derivation of β-cells from human pluripotent stem cells.
    Authors: Afrikanova Et al.
    J Biol Chem  2011;286:36042
  15. GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation.
    Authors: Tu Et al.
    J Neurosci  2010;30:749
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