hh FAK Inhibitor 14 (CAS 4506-66-5): R&D Systems
Catalog Number: 3414
Alternate Names: Y15, NSC 677249
Chemical Name: 1,2,4,5-Benzenetetramine tetrahydrochloride
Biological Activity
Selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. Prevents FAK autophosphorylation at Y397 (IC50 = 1 μM), promotes cell detachment and inhibits cell adhesion in vitro. Exhibits antiproliferative activity in a variety of human tumor cell lines in vitro and in breast cancer cells in vivo.
Technical Data
  • M.Wt:
    284.01
  • Formula:
    C6H10N4.4HCl
  • Solubility:
    Soluble to 50 mM in water and to 75 mM in DMSO
  • Storage:
    Desiccate at RT
  • CAS No:
    4506-66-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the Y397 site of focal adhesion kinase decreases tumour growth.
    Golubovskaya et al.
    J.Med.Chem., 2008;51:7405
  2. A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.
    Hochwald et al.
    Cell Cycle, 2009;8:2435
Citations:

The citations listed below are publications that use Tocris products. Selected citations for FAK Inhibitor 14 include:

11 Citations: Showing 1 - 10
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  1. Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
    Authors: Visavadiya
    Cell Communication and Signaling 2016;14:32
  2. Endothelial Cells Use a Formin-Dependent Phagocytosis-Like Process to Internalize the Bacterium Listeria monocytogenes.
    Authors: Rengarajan Et al.
    PLoS One 2016;12:e1005603
  3. Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells.
    Authors: Webber Et al.
    Oncoscience 2015;2:765
  4. RECK-Mediated β1-Integrin Regulation by TGF-β1 Is Critical for Wound Contraction in Mice.
    Authors: Gutiérrez Et al.
    J Neurosci 2015;10:e0135005
  5. Astroglial-derived periostin promotes axonal regeneration after spinal cord injury.
    Authors: Shih Et al.
    Auton Neurosci 2014;34:2438
  6. ERBB4 confers metastatic capacity in Ewing sarcoma.
    Authors: Mendoza-Naranjo Et al.
    EMBO Mol Med 2013;5:1019
  7. Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis.
    Authors: Wiel Et al.
    Cell Death Dis 2013;4:e855
  8. CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release.
    Authors: Malenczyk Et al.
    J Biol Chem 2013;288:32685
  9. Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression.
    Authors: Keasey Et al.
    Cell Commun Signal 2013;11:35
  10. Inhibitors of Src and focal adhesion kinase promote endocrine specification: impact on the derivation of β-cells from human pluripotent stem cells.
    Authors: Afrikanova Et al.
    J Biol Chem 2011;286:36042
  11. GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation.
    Authors: Tu Et al.
    J Neurosci 2010;30:749
Expand to show all 11 Citations

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