FAK Inhibitor 14

Tocris Bioscience | Catalog # 3414

Selective FAK inhibitor
Tocris Bioscience

Key Product Details

Description

Selective FAK inhibitor

Alternative Names

Y15,NSC 677249
View all Focal Adhesion Kinase Inhibitors »

Product Description

FAK Inhibitor 14 is a selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. FAK Inhibitor 14 prevents FAK autophosphorylation at Y397 (IC50 = 1 μM), promotes cell detachment and inhibits cell adhesion in vitro. FAK Inhibitor 14 exhibits antiproliferative activity in a variety of human tumor cell lines in vitro and in breast cancer cells in vivo.

Product Specifications for FAK Inhibitor 14

Molecular Weight

284.01

Formula

C6H10N4.4HCl

Storage

Desiccate at RT

Chemical Name

1,2,4,5-Benzenetetramine tetrahydrochloride

CAS Number

4506-66-5

PubChem ID

78260

InChI Key

BZDGCIJWPWHAOF-UHFFFAOYSA-N

SMILES

NC1=C(N)C=C(N)C(N)=C1.Cl.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 14.2 50
DMSO 21.3 75

Preparing Stock Solutions for FAK Inhibitor 14

The following data is based on the product molecular weight 284.01.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 4.69 mL 23.47 mL 46.95 mL
3.75 mM 0.94 mL 4.69 mL 9.39 mL
7.5 mM 0.47 mL 2.35 mL 4.69 mL
37.5 mM 0.09 mL 0.47 mL 0.94 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 90 publications citing the usage of this product.

Product Documents for FAK Inhibitor 14

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for FAK Inhibitor 14

For research use only

Citations for FAK Inhibitor 14

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  • Mitochondrial bioenergetics measurements by reagent screen
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: mouse brain endothelioma cell line
    Verified Customer | Posted 03/15/2020
    10 μM
    FAK Inhibitor 14 3414

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