FAK Inhibitor 14

Catalog # Availability Size / Price Qty
3414/10
3414/50
FAK Inhibitor 14 | CAS No. 4506-66-5 | Focal Adhesion Kinase Inhibitors
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Description: Selective FAK inhibitor
Alternative Names: Y15, NSC 677249

Chemical Name: 1,2,4,5-Benzenetetramine tetrahydrochloride

Product Details
Citations (19)
Reviews

Biological Activity

Selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. Prevents FAK autophosphorylation at Y397 (IC50 = 1 μM), promotes cell detachment and inhibits cell adhesion in vitro. Exhibits antiproliferative activity in a variety of human tumor cell lines in vitro and in breast cancer cells in vivo.

Technical Data

M.Wt:
284.01
Formula:
C6H10N4.4HCl
Solubility:
Soluble to 50 mM in water and to 75 mM in DMSO
Storage:
Desiccate at RT
CAS No:
4506-66-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for FAK Inhibitor 14

The citations listed below are publications that use Tocris products. Selected citations for FAK Inhibitor 14 include:

19 Citations: Showing 1 - 10

  1. Fibroblast activation protein-α promotes the growth and migration of lung cancer cells via the PI3K and sonic hedgehog pathways.
    Authors: Jia Et al.
    Int J Mol Med  2018;41:275
  2. Matrix stiffness modulates infection of endothelial cells by Listeria monocytogenes via expression of cell surface vimentin.
    Authors: Bastounis Et al.
    Mol Biol Cell  2018;29:1571
  3. Plectin protects podocytes from adriamycin-induced apoptosis and F-actin cytoskeletal disruption through the integrin α6β4/FAK/p38 MAPK pathway.
    Authors: Ni Et al.
    J Cell Mol Med  2018;22:5450
  4. Netrin-1 suppresses the MEK/ERK pathway and ITGB4 in pancreatic cancer.
    Authors: An Et al.
    Oncotarget  2016;7:24719
  5. Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
    Authors: Visavadiya
    Cell Communication and Signaling  2016;14:32
  6. Endothelial Cells Use a Formin-Dependent Phagocytosis-Like Process to Internalize the Bacterium Listeria monocytogenes.
    Authors: Rengarajan Et al.
    PLoS One  2016;12:e1005603
  7. Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer.
    Authors: Thakur Et al.
    Sci Rep  2015;5:10194
  8. Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells.
    Authors: Webber Et al.
    Oncoscience  2015;2:765
  9. RECK-Mediated β1-Integrin Regulation by TGF-β1 Is Critical for Wound Contraction in Mice.
    Authors: Gutiérrez Et al.
    J Neurosci  2015;10:e0135005
  10. Palladin mediates stiffness-induced fibroblast activation in the tumor microenvironment.
    Authors: McLane and Ligon
    Biophys J  2015;109:249

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