Catalog Number: 3414
Alternate Names: Y15, NSC 677249
Chemical Name: 1,2,4,5-Benzenetetramine tetrahydrochloride
Biological Activity
Selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. Prevents FAK autophosphorylation at Y397 (IC50 = 1 μM), promotes cell detachment and inhibits cell adhesion in vitro. Exhibits antiproliferative activity in a variety of human tumor cell lines in vitro and in breast cancer cells in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in water and to 75 mM in DMSO
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the Y397 site of focal adhesion kinase decreases tumour growth.
    Golubovskaya et al.
    J.Med.Chem., 2008;51:7405
  2. A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.
    Hochwald et al.
    Cell Cycle, 2009;8:2435

The citations listed below are publications that use Tocris products. Selected citations for FAK Inhibitor 14 include:

Showing Results 1 - 10 of 10

  1. Endothelial Cells Use a Formin-Dependent Phagocytosis-Like Process to Internalize the Bacterium Listeria monocytogenes.
    Authors: Rengarajan Et al.
    PLoS One
  2. Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells.
    Authors: Webber Et al.
  3. RECK-Mediated β1-Integrin Regulation by TGF-β1 Is Critical for Wound Contraction in Mice.
    Authors: Gutiérrez Et al.
    J Neurosci
  4. Astroglial-derived periostin promotes axonal regeneration after spinal cord injury.
    Authors: Shih Et al.
    Auton Neurosci
  5. ERBB4 confers metastatic capacity in Ewing sarcoma.
    Authors: Mendoza-Naranjo Et al.
    EMBO Mol Med
  6. Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis.
    Authors: Wiel Et al.
    Cell Death Dis
  7. CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release.
    Authors: Malenczyk Et al.
    J Biol Chem
  8. Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression.
    Authors: Keasey Et al.
    Cell Commun Signal
  9. Inhibitors of Src and focal adhesion kinase promote endocrine specification: impact on the derivation of β-cells from human pluripotent stem cells.
    Authors: Afrikanova Et al.
    J Biol Chem
  10. GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation.
    Authors: Tu Et al.
    J Neurosci
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information

Molarity Calculator
Calculate the mass, volume or concentration required for a solution

The molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol)
An example of a molarity calculation using the molarity calculator:
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?

R&D Systems Guarantee

or select another batch:


Customer Information