Biological ActivityFAM-DEALAHypYIPMDDDFQLRSF is a 5-carboxyfluorescein (FAM) labeled HIF-1α peptide. It binds with high affinity to von Hippel-Lindau (VHL) protein (KD = 3 nM). Can be used to assess ligand binding to VHL in a direct fluorescence polarization (FP) displacement assay. Excitation/emission maxima (λ) = 485/520 nm. This product is a longer peptide version of FAM-DEALA-Hyp-YIPD (Cat. No. 7287).
Optical Data for FAM-DEALAHypYIPMDDDFQLRSF
|Closest Laser line||488 nm|
|Application||FP assay to determine VHL binding affinity, useful for PROTAC/Degrader development|
(Modifications: Asp-1 = 5-FAM-Asp, X-6 = Hyp, Phe-19 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification and characterization of Von Hippel-Lindau-recruiting proteolysis targeting chimeras (PROTACs) of TANK-binding kinase 1.
Crew et al.
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