Fatostatin A
Chemical Name: 4-[4-(4-Methylphenyl)-2-thiazolyl]-2-propylpyridine hydrobromide
Purity: ≥97%
Biological Activity
Fatostatin A is an inhibitor of sterol regulatory element binding protein (SREBP); impairs the activation of SREBP-1 and SREBP-2. Exhibits antiproliferative effects in DU 145 cells independently of IGF-1 signaling (IC50 = 0.1 μM); reverses hyperglycemia in diabetic (ob/ob) mice. Cell permeable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.
Kamisuki et al.
Chem.Biol., 2009;16:882 -
Identification of bioactive molecules by adipogenesis profiling of organic compounds.
Choi et al.
J.Biol.Chem., 2003;278:7320
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Citation for Fatostatin A
The citations listed below are publications that use Tocris products. Selected citations for Fatostatin A include:
1 Citation: Showing 1 - 1
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Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation.
Authors: Roche Et al.
J Cell Biol 2018;217:3560
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