Inhibitor of sterol regulatory element binding protein (SREBP); impairs the activation of SREBP-1 and SREBP-2. Exhibits antiproliferative effects in DU 145 cells independently of IGF-1 signaling (IC50
= 0.1 μ
M); reverses hyperglycemia in diabetic (ob/ob
) mice. Cell permeable.
Soluble to 20 mM in DMSO
Store at +4°C
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All Tocris products are intended for laboratory research use only.
A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.
Kamisuki et al.
Identification of bioactive molecules by adipogenesis profiling of organic compounds.
Choi et al.