Chemical Name: Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
Biological ActivityA very potent uncoupler of oxidative phosphorylation in mitochondria.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Novel effects of FCCP [carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone] on amyloid precursor protein processing.
Connop et al.
A new class of uncoupling agents - carbonyl cyanide phenylhydrazones.
Heytler and Pritchard
Citations for FCCP
The citations listed below are publications that use Tocris products. Selected citations for FCCP include:
12 Citations: Showing 1 - 10
Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity.
Authors: Panja Et al.
Neuropathol Appl Neurobiol 2019;45:141
A nanoscale, multi-parametric flow cytometry-based platform to study mitochondrial heterogeneity and mitochondrial DNA dynamics.
Authors: MacDonald Et al.
Commun Biol 2019;2:258
Human immunodeficiency virus Tat impairs mitochondrial fission in neurons.
Authors: Rozzi Et al.
Cell Death Discov 2018;4:8
Mitochondrial membrane depolarization enhances TRAIL-induced cell death in adult human granulosa tumor cells, KGN, through inhibition of BIRC5.
Authors: MacDonald Et al.
J Ovarian Res 2018;11:89
PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.
Authors: Banh Et al.
Nat Cell Biol 2016;18:803
Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
Cell Communication and Signaling 2016;14:32
The free radical scavenger Trolox dampens neuronal hyperexcitability, reinstates synaptic plasticity, and improves hypoxia tolerance in a mouse model of Rett syndrome.
Front Cell Neurosci 2014;8:56
Divergent effects of painful nerve injury on mitochondrial Ca(2+) buffering in axotomized and adjacent sensory neurons.
Authors: Hogan Et al.
Brain Res 2014;1589:112
BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria.
Authors: Choubey Et al.
9-Phenanthrol and flufenamic acid inhibit calcium oscillations in HL-1 mouse cardiomyocytes.
Authors: Burt Et al.
Cell Calcium 2013;54:193
Temporo-spectral imaging of intrinsic optical signals during hypoxia-induced spreading depression-like depolarization.
Authors: Mané and Müller
PLoS One 2012;7:e43981
H(2)O(2)-mediated modulation of cytosolic signaling and organelle function in rat hippocampus.
Authors: Gerich Et al.
J Pharmacol Exp Ther 2009;458:937
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4 μM FCCP