Catalog Number: 0453
Chemical Name: Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
Biological Activity
A very potent uncoupler of oxidative phosphorylation in mitochondria.
Technical Data
  • M.Wt:
    254.17
  • Formula:
    C10H5F3N4O
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    370-86-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A new class of uncoupling agents - carbonyl cyanide phenylhydrazones.
    Heytler and Pritchard
    Biochem.Biophys.Res.Commun., 1962;7:272
  2. Novel effects of FCCP [carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone] on amyloid precursor protein processing.
    Connop et al.
    J.Neurochem., 1999;72:1457
Citations:

The citations listed below are publications that use Tocris products. Selected citations for FCCP include:

3 Citations: Showing 1 - 3
Filter your results:

  1. Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
    Authors: Visavadiya
    Cell Communication and Signaling 2016;14:32
  2. BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria.
    Authors: Choubey Et al.
    Autophagy 2014;10:1105
  3. H(2)O(2)-mediated modulation of cytosolic signaling and organelle function in rat hippocampus.
    Authors: Gerich Et al.
    J Pharmacol Exp Ther 2009;458:937

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