Catalog # Availability Size / Price Qty
FCCP | CAS No. 370-86-5 | Oxidative Phosphorylation Uncouplers
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Description: Oxidative phosphorylation uncoupler

Chemical Name: Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone

Purity: ≥99%

Product Details
Citations (12)
Reviews (2)

Biological Activity

A very potent uncoupler of oxidative phosphorylation in mitochondria.

Technical Data

Soluble to 100 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for FCCP

The citations listed below are publications that use Tocris products. Selected citations for FCCP include:

12 Citations: Showing 1 - 10

  1. Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity.
    Authors: Panja Et al.
    Neuropathol Appl Neurobiol  2019;45:141
  2. A nanoscale, multi-parametric flow cytometry-based platform to study mitochondrial heterogeneity and mitochondrial DNA dynamics.
    Authors: MacDonald Et al.
    Commun Biol  2019;2:258
  3. Human immunodeficiency virus Tat impairs mitochondrial fission in neurons.
    Authors: Rozzi Et al.
    Cell Death Discov  2018;4:8
  4. Mitochondrial membrane depolarization enhances TRAIL-induced cell death in adult human granulosa tumor cells, KGN, through inhibition of BIRC5.
    Authors: MacDonald Et al.
    J Ovarian Res  2018;11:89
  5. PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.
    Authors: Banh Et al.
    Nat Cell Biol  2016;18:803
  6. Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
    Authors: Visavadiya
    Cell Communication and Signaling  2016;14:32
  7. The free radical scavenger Trolox dampens neuronal hyperexcitability, reinstates synaptic plasticity, and improves hypoxia tolerance in a mouse model of Rett syndrome.
    Authors: Janc
    Front Cell Neurosci  2014;8:56
  8. Divergent effects of painful nerve injury on mitochondrial Ca(2+) buffering in axotomized and adjacent sensory neurons.
    Authors: Hogan Et al.
    Brain Res  2014;1589:112
  9. BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria.
    Authors: Choubey Et al.
    Autophagy  2014;10:1105
  10. 9-Phenanthrol and flufenamic acid inhibit calcium oscillations in HL-1 mouse cardiomyocytes.
    Authors: Burt Et al.
    Cell Calcium  2013;54:193


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We got expected effect on cells
By Anonymous on 04/03/2020
Application: Species: Mouse


Mitochondrial bioenergetics measurements by reagent screen
By Anonymous on 03/15/2020
Application: Species: Mouse

1 μM

PMID: 27978828

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