Chemical Name: Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
Biological ActivityA very potent uncoupler of oxidative phosphorylation in mitochondria.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Novel effects of FCCP [carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone] on amyloid precursor protein processing.
Connop et al.
A new class of uncoupling agents - carbonyl cyanide phenylhydrazones.
Heytler and Pritchard
Citations for FCCP
The citations listed below are publications that use Tocris products. Selected citations for FCCP include:
12 Citations: Showing 1 - 10
Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity.
Authors: Panja Et al.
Neuropathol Appl Neurobiol 2019;45:141
A nanoscale, multi-parametric flow cytometry-based platform to study mitochondrial heterogeneity and mitochondrial DNA dynamics.
Authors: MacDonald Et al.
Commun Biol 2019;2:258
Human immunodeficiency virus Tat impairs mitochondrial fission in neurons.
Authors: Rozzi Et al.
Cell Death Discov 2018;4:8
Mitochondrial membrane depolarization enhances TRAIL-induced cell death in adult human granulosa tumor cells, KGN, through inhibition of BIRC5.
Authors: MacDonald Et al.
J Ovarian Res 2018;11:89
PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.
Authors: Banh Et al.
Nat Cell Biol 2016;18:803
Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
Cell Communication and Signaling 2016;14:32
The free radical scavenger Trolox dampens neuronal hyperexcitability, reinstates synaptic plasticity, and improves hypoxia tolerance in a mouse model of Rett syndrome.
Front Cell Neurosci 2014;8:56
Divergent effects of painful nerve injury on mitochondrial Ca(2+) buffering in axotomized and adjacent sensory neurons.
Authors: Hogan Et al.
Brain Res 2014;1589:112
BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria.
Authors: Choubey Et al.
9-Phenanthrol and flufenamic acid inhibit calcium oscillations in HL-1 mouse cardiomyocytes.
Authors: Burt Et al.
Cell Calcium 2013;54:193
Temporo-spectral imaging of intrinsic optical signals during hypoxia-induced spreading depression-like depolarization.
Authors: Mané and Müller
PLoS One 2012;7:e43981
H(2)O(2)-mediated modulation of cytosolic signaling and organelle function in rat hippocampus.
Authors: Gerich Et al.
J Pharmacol Exp Ther 2009;458:937
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