Non-purine inhibitor of xanthine oxidase (Ki
= 1.2 nM). Binds to a channel leading to the enzyme active site; obstructs substrate binding.
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All Tocris products are intended for laboratory research use only.
Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in rodents.
Osada et al.
Xanthine oxidase inhibition with febuxostat attenuates systolic overload-induced left ventricular hypertrophy and dysfunction in mice.
Xu et al.
An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition.
Okamoto et al.
The citations listed below are publications that use Tocris products. Selected citations for Febuxostat include:
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