Chemical Name: 2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid
Biological ActivityNon-purine inhibitor of xanthine oxidase (Ki = 1.2 nM). Binds to a channel leading to the enzyme active site; obstructs substrate binding.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in rodents.
Osada et al.
An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition.
Okamoto et al.
Xanthine oxidase inhibition with febux. attenuates systolic overload-induced left ventricular hypertrophy and dysfunction in mice.
Xu et al.
Citations for Febuxostat
The citations listed below are publications that use Tocris products. Selected citations for Febuxostat include:
2 Citations: Showing 1 - 2
Febuxostat improves outcome in a rat model of cancer cachexia.
Authors: Konishi Et al.
Front Cell Neurosci 2015;6:174
OE shapes auditory processing in the adult brain by regulating inhibitory transmission and plasticity-associated gene expression.
Authors: Tremere Et al.
J Neurosci 2009;29:5949
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