Catalog Number: 4427
Alternate Names: TEI 6720, TMX 67
Chemical Name: 2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid
Biological Activity
Non-purine inhibitor of xanthine oxidase (Ki = 1.2 nM). Binds to a channel leading to the enzyme active site; obstructs substrate binding.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 75 mM in DMSO and to 50 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in rodents.
    Osada et al.
    Eur.J.Pharmacol., 1993;241:183
  2. Xanthine oxidase inhibition with febuxostat attenuates systolic overload-induced left ventricular hypertrophy and dysfunction in mice.
    Xu et al.
    J.Card.Fail., 2008;14:746
  3. An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition.
    Okamoto et al.
    J.Biol.Chem., 2003;278:1848

The citations listed below are publications that use Tocris products. Selected citations for Febuxostat include:

1 Citations: Showing 1 - 1

  1. Febuxostat improves outcome in a rat model of cancer cachexia.
    Authors: Konishi Et al.
    Front Cell Neurosci 2015;6:174

Have you used Febuxostat?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information


Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee


Customer Information