Chemical Name: N-(3,3-Diphenylpropyl)-α-methylbenzylamine hydrochloride
Biological ActivityFendiline Hydrochloride is a K-Ras inhibitor. Selectively inhibits K-Ras localization to the plasma membrane (IC50 = 9.64 μM). Blocks proliferation of cancer cell lines expressing oncogenic mutant K-Ras. Also inhibits L-type calcium channels (IC50 = 17 μM).
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Fendiline inhibits L-type calcium channels in guinea-pig ventricular myocytes: a whole-cell patch-clamp study.
Tripathi et al.
Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission.
van der Hoeven et al.
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