Fendiline Hydrochloride

Key Product Details

Product Description

Fendiline Hydrochloride is a K-Ras inhibitor. Selectively inhibits K-Ras localization to the plasma membrane (IC₅₀ = 9.64 μM). Blocks proliferation of cancer cell lines expressing oncogenic mutant K-Ras. Also inhibits L-type calcium channels (IC₅₀ = 17 μM).

Product Specifications for Fendiline Hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Fendiline Hydrochloride

The following data is based on the product molecular weight 351.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.84 mL	14.21 mL	28.42 mL
5 mM	0.57 mL	2.84 mL	5.68 mL
10 mM	0.28 mL	1.42 mL	2.84 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• van der Hoeven Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission. Mol.Cell.Biol. 2015 PMID: 23129805
• Tripathi Fendiline inhibits L-type calcium channels in guinea-pig ventricular myocytes: a whole-cell patch-clamp study. Br.J.Pharmacol. 1993 PMID: 8485628

Product Documents for Fendiline Hydrochloride