Catalog Number: 5200
Chemical Name: 4-(2-Aminoethyl)-6-chloro-7-hydroxy-2H-1-benzopyran-2-one methanesulfonate
Biological Activity
pH responsive fluorescent false neurotransmitter (FFN). Selective dopamine transporter (DAT) and VMAT2 substrate. Exhibits no significant binding to a panel of 38 CNS receptors, including dopamine and serotonin receptors. Inhibits dopamine uptake.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Columbia University.
Background References
  1. Fluorescent dopamine tracer resolves individual dopaminergic synapses and their activity in the brain.
    Rodriguez et al.
    Proc.Natl.Acad.Sci.U.S.A., 2013;110:870
  2. Visualizing neurotransmitter secretion at individual synapses.
    Sames et al.
    ACS Chem.Neurosci., 2013;4:648
  3. Development of pH-responsive fluorescent false neurotransmitters.
    Lee et al.
    J.Am.Chem.Soc., 2010;132:8828
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