FFN 102 mesylate

Catalog # Availability Size / Price Qty
5200/10
Cat.No. 5200 - FFN 102 mesylate | C11H11N2ClO3.CH3SO3H
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Description: Selective fluorescent substrate of DAT and VMAT2

Chemical Name: 4-(2-Aminoethyl)-6-chloro-7-hydroxy-2H-1-benzopyran-2-one methanesulfonate

Purity: ≥99%

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Biological Activity

pH responsive fluorescent false neurotransmitter (FFN). Selective dopamine transporter (DAT) and VMAT2 substrate. Exhibits no significant binding to a panel of 38 CNS receptors, including dopamine and serotonin receptors. Inhibits dopamine uptake. Excitation maxima are 340 nm at pH 5 and 370 nm at pH 7.5. Emission maximum is 435 nm at both pH 5 and 7.5.

Technical Data

M.Wt:
335.76
Formula:
C11H11N2ClO3.CH3SO3H
Solubility:
Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Columbia University.

Background References

  1. Fluorescent dopamine tracer resolves individual dopaminergic synapses and their activity in the brain.
    Rodriguez et al.
    Proc.Natl.Acad.Sci.U.S.A., 2013;110:870
  2. Visualizing neurotransmitter secretion at individual synapses.
    Sames et al.
    ACS Chem.Neurosci., 2013;4:648
  3. Development of pH-responsive fluorescent false neurotransmitters.
    Lee et al.
    J.Am.Chem.Soc., 2010;132:8828

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