Chemical Name: 3-(2-Aminoethyl)-8-fluoro-7-hydroxy-2H-chromen-2-one hydrochloride
Biological ActivityFluorescent false neurotransmitter (FFN). Fluorescent substrate for NET and VMAT2. Labels noradrenergic neurons and their synaptic vesicles, and enables imaging of synaptic vesicle content release from specific axonal sites in vivo. Selectively labels NA neurons over other monoamine and CNS targets. Exhibits two resolved absorption/excitation maxima depending on solvent pH (excitation maxima: 320 nm or 365 nm, emission maxima: 475 nm).
Amphetamine-stimulated release of FFN 270 from noradrenergic projections
Amphetamine releases FFN 270 from noradrenergic projections in vivo. The video shows FFN 270 puncta in Layer 1 of the barrel cortex in mice taken before and after injection of amphetamine (AMPH).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Designing a norepinephrine optical tracer for imaging individual noradrenergic synapses and their activity in vivo.
Dunn et al.
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