Catalog Number: 0554
Chemical Name: N-Methyl-β-carboline-3-carboxamide
Biological Activity
Inverse agonist and anxiogenic agent. Increases tyrosine hydroxylation and causes upregulation of β-adrenoceptors in mouse cerebral cortex.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 75 mM in 1eq. HCl and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Evidence for an excitatory action of benzodiazepine receptor inverse agonist FG 7142 on C-fibre afferents.
    Donner et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1989;340:352
  2. The anxiogenic β-carboline FG-7142 increases in vivo and in vitro tyrosine hydroxylation in the prefrontal cortex.
    Knorr et al.
    Brain Res., 1989;495:355
  3. Behavioural studies with the β-carboline FG 7142 combined with related drugs in monkeys.
    Eur.J.Pharmacol., 1989;163:219
  4. A single dose of FG 7142 causes long term increases in mouse cortical β-adrenoceptors.
    Stanford et al.
    Eur.J.Pharmacol., 1987;134:313
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