Inverse agonist and anxiogenic agent. Increases tyrosine hydroxylation and causes upregulation of β
-adrenoceptors in mouse cerebral cortex.
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Evidence for an excitatory action of benzodiazepine receptor inverse agonist FG 7142 on C-fibre afferents.
Donner et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1989;340:352
The anxiogenic β-carboline FG-7142 increases in vivo and in vitro tyrosine hydroxylation in the prefrontal cortex.
Knorr et al.
Brain Res., 1989;495:355
Behavioural studies with the β-carboline FG 7142 combined with related drugs in monkeys.
A single dose of FG 7142 causes long term increases in mouse cortical β-adrenoceptors.
Stanford et al.
The citations listed below are publications that use Tocris products. Selected citations for FG 7142 include:
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