Catalog Number: 6250
Chemical Name: (3R,4S,6S,8S,10R,12R,14R,16S,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,16,27-Octahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyloxacyclooctacosa-17,19,21,23,25-pentaen-2-one
Biological Activity
Polyene antibiotic. Binds sterols in fungal membranes. Also inhibits formation of the pathological form of prion protein (PrP-res) from the normal membrane-bound (PrP-sen) form. Also fluorescent cholesterol stain.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 5 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Absorption and fluorescence spectra of polyene antibiotics in the presence of cholesterol.
    Castanho et al.
    J.Biol.Chem., 1992;267:204
  2. Filipin prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular PrP release.
    Marella et al.
    J.Biol.Chem., 2002;277:25457
  3. Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells.
    Pipalia et al.
    J.Lipid Res., 2006;47:284
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