FIPI

  ( 3 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:3600
Chemical Name:N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethy]-5-fluoro-1H-indole-2-carboxamide hydrochloride
Product Details
Citations (3)
Reviews
Biological Activity
Potent phosholipase D (PLD) inhibitor (IC50 values are 20 and 25 nM for PLD2 and PLD1 respectively). Ameliorates PLD2-driven suppression of membrane ruffling and cell spreading. Orally available.
Technical Data
  • M.Wt:
    457.93
  • Formula:
    C23H24FN5O2.HCl
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    939055-18-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for FIPI include:

3 Citations: Showing 1 - 3
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  1. The prostaglandin E2-EP3 receptor axis regulates Anaplasma phagocytophilum-mediated NLRC4 inflammasome activation.
    Authors: Wang Et al.
    PLoS Pathog.  2016;12:e1005803
  2. Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-xL strategies through Mcl-1 down-regulation.
    Authors: Bonnefond Et al.
    Int J Mol Sci  2015;20:535
  3. Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs.
    Authors: Pastor Et al.
    J Lipid Res  2014;55:966

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Average Rating: 5 (Based on 1 review)

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Summary

Species Mouse
Pub Med ID 27482714

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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