Catalog Number: 3600
Chemical Name: N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethy]-5-fluoro-1H-indole-2-carboxamide hydrochloride
Biological Activity
Potent phosholipase D (PLD) inhibitor (IC50 values are 20 and 25 nM for PLD2 and PLD1 respectively). Ameliorates PLD2-driven suppression of membrane ruffling and cell spreading. Orally available.
Technical Data
  • M.Wt:
    457.93
  • Formula:
    C23H24FN5O2.HCl
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    939055-18-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Optimization of halopemide for phospholipase D2 inhibition.
    Monovich et al.
    Bioorg.Med.Chem.Lett., 2007;17:2310
  2. 5-fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis.
    Su et al.
    Mol.Pharmcol., 2009;75:43
Citations:

The citations listed below are publications that use Tocris products. Selected citations for FIPI include:

2 Citations: Showing 1 - 2
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  1. The prostaglandin E2-EP3 receptor axis regulates Anaplasma phagocytophilum-mediated NLRC4 inflammasome activation.
    Authors: Wang Et al.
    PLoS Pathog. 2016;12:e1005803
  2. Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-xL strategies through Mcl-1 down-regulation.
    Authors: Bonnefond Et al.
    Int J Mol Sci 2015;20:535

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