FIPI

Catalog # Availability Size / Price Qty
3600/10
3600/50
FIPI | CAS No. 1781834-93-2 | Phospholipase Inhibitors
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Description: Phospholipase D inhibitor

Chemical Name: N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethy]-5-fluoro-1H-indole-2-carboxamide hydrochloride

Purity: ≥98%

Product Details
Citations (5)
Reviews (1)

Biological Activity

Potent phosholipase D (PLD) inhibitor (IC50 values are 20 and 25 nM for PLD2 and PLD1 respectively). Ameliorates PLD2-driven suppression of membrane ruffling and cell spreading. Orally available.

Technical Data

M.Wt:
457.93
Formula:
C23H24FN5O2.HCl
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1781834-93-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Optimization of halopemide for phospholipase D2 inhibition.
    Monovich et al.
    Bioorg.Med.Chem.Lett., 2007;17:2310
  2. 5-fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis.
    Su et al.
    Mol.Pharmcol., 2009;75:43

Product Datasheets

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used this drug as an inhibitor
By Anonymous on 10/05/2017
Species: Mouse

Pretreat mouse macrophage cells with this inhibitor prior to the bacterial stimulation.

PMID: 27482714

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