FK 3311

Catalog # Availability Size / Price Qty
2776/10
2776/1
Cyclooxygenase Inhibitors Small Molecule
1 Image
Description: Cyclooxygenase-2 (COX-2) inhibitor

Chemical Name: N-[4-Acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide

Purity: ≥98%

Product Details
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Biological Activity

Cyclooxygenase-2 (COX-2) inhibitor. Inhibits zymosan-induced prostaglandin E2 production by rat peritoneal neutrophils in vitro and adjuvant-induced arthritis in vivo. Anti-inflammatory.

Technical Data

M.Wt:
341.33
Formula:
C15H13F2NO4S
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
116686-15-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Studies on antiinflammatory agents. I. Synthesis and pharmacological properties of 2'-phenoxy-methanesulfonanilide derivatives.
    Tsuji et al.
    Chem.Pharm.Bull., 1992;40:2399
  2. Effects of the COX-2 inhibitor FK3311 on ischemia-reperfusion injury in the rat lung.
    Otani et al.
    J.Invest.Surg., 2007;20:175
  3. Studies on antiinflammatory agents. III. Synthesis and pharmacological properties of metabolites of 4'-acetyl-2'-(2,4-difluorophenoxy)methanesulfonanilide (FK3311).
    Nakamura et al.
    Chem.Pharm.Bull., 1993;41

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