Chemical Name: N-[4-Acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide
Biological ActivityCyclooxygenase-2 (COX-2) inhibitor. Inhibits zymosan-induced prostaglandin E2 production by rat peritoneal neutrophils in vitro and adjuvant-induced arthritis in vivo. Anti-inflammatory.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Studies on antiinflammatory agents. I. Synthesis and pharmacological properties of 2'-phenoxy-methanesulfonanilide derivatives.
Tsuji et al.
Effects of the COX-2 inhibitor FK3311 on ischemia-reperfusion injury in the rat lung.
Otani et al.
Studies on antiinflammatory agents. III. Synthesis and pharmacological properties of metabolites of 4'-acetyl-2'-(2,4-difluorophenoxy)methanesulfonanilide (FK3311).
Nakamura et al.
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