FK 3311

Discontinued Product

2776 has been discontinued.
View all Cyclooxygenase Inhibitors products.
FK 3311 | CAS No. 116686-15-8 | Cyclooxygenase Inhibitors
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Description: Cyclooxygenase-2 (COX-2) inhibitor

Chemical Name: N-[4-Acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide

Purity: ≥98%

Product Details

Biological Activity

FK 3311 is a cyclooxygenase-2 (COX-2) inhibitor. Inhibits zymosan-induced prostaglandin E2 production by rat peritoneal neutrophils in vitro and adjuvant-induced arthritis in vivo. Anti-inflammatory.

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in ethanol
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Studies on antiinflammatory agents. I. Synthesis and pharmacological properties of 2'-phenoxy-methanesulfonanilide derivatives.
    Tsuji et al.
    Chem.Pharm.Bull., 1992;40:2399
  2. Effects of the COX-2 inhibitor FK3311 on ischemia-reperfusion injury in the rat lung.
    Otani et al.
    J.Invest.Surg., 2007;20:175
  3. Studies on antiinflammatory agents. III. Synthesis and pharmacological properties of metabolites of 4'-acetyl-2'-(2,4-difluorophenoxy)methanesulfonanilide (FK3311).
    Nakamura et al.
    Chem.Pharm.Bull., 1993;41

Product Datasheets

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