Chemical Name: N-Methyl-3-[(4-trifluoromethyl)phenoxy]-3-phenylpropylamine hydrochloride
Biological ActivityFluoxetine hydrochloride is a selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a Ki of 0.9 nmol/l and is between 150- and 900-fold selective over 5-HT1A, 5-HT2A, H1, α1, α2-adrenergic, and muscarinic receptors. Antidepressant. Induces differentiation of neuronal precursors, enhancing neuronal characteristics. Fluoxetine also inhibits assembly and activation of the NLRP3-ASC inflammasome and prevents degeneration of retinal pigmented epithelium (RPE) cells in an animal model of dry age-related macular degeneration (AMD).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Increased cellular turnover in response to fluoxetine in neuronal precursors derived from human embryonic stem cells.
Chang et al.
Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.
Owens et al.
Fluoxetine selectively alters 5-hydroxytryptamine1A and γ-aminobutyric acidB receptor-mediated hyperpolarization in area CA1, but not area CA3, hippocampal pyramidal cells.
Beck et al.
Fluoxetine. A review of its pharmacodynamic properties, and therapeutic efficacy in depressive illness.
Benfield et al.
Increased cellular turnover in response to fluox. in neuronal precursors derived from human embryonic stem cells.
Chang et al.
Identification of fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration.
Ambati et al.
Citations for Fluoxetine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Fluoxetine hydrochloride include:
10 Citations: Showing 1 - 10
Auto-Reactive Th17-Cells Trigger Obsessive-Compulsive-Disorder Like Behavior in Mice With Experimental Autoimmune Encephalomyelitis.
Authors: Kant Et al.
Front Immunol 2018;9:2508
Acute stress is detrimental to heart regeneration in zebrafish.
Authors: Sallin and Jazwinska
Open Biol 2016;6
Functional integration of a serotonergic neuron in the Drosophila antennal lobe.
Authors: Zhang and Gaudry
Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero.
Authors: Hooper Et al.
Am J Physiol Heart Circ Physiol 2016;311:H572
Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation.
Authors: Pai Et al.
J Neurosci 2015;35:4366
Serotonin receptors expressed in Drosophila mushroom bodies differentially modulate larval locomotion.
Authors: Silva Et al.
PLoS One 2014;9:e89641
A translational rodent assay of affective biases in depression and antidepressant therapy.
Authors: Stuart Et al.
HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity.
Authors: Kurita Et al.
Nat Neurosci 2012;15:1245
TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells.
Authors: Nozawa Et al.
Proc Natl Acad Sci U S A 2009;106:3408
Overexpression of the 5-hydroxytryptamine transporter gene: effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension.
Authors: MacLean Et al.
J Pharmacol Exp Ther 2004;109:2150
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