Fluoxetine hydrochloride

  ( 7 citations )    
Product Datasheet
Catalog Number:0927
Chemical Name:N-Methyl-3-[(4-trifluoromethyl)phenoxy]-3-phenylpropylamine hydrochloride
Product Details
Citations (7)
Supplemental Products
Reviews
Biological Activity
Selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a Ki of 0.9 nmol/l and is between 150- and 900- fold selective over 5-HT1A, 5-HT2A, H1, α1, α2-adrenergic, and muscarinic receptors. Antidepressant. Induces differentiation of neuronal precursors, enhancing neuronal characteristics.

Deuterated analog also available.

Technical Data
  • M.Wt:
    345.78
  • Formula:
    C17H18F3NO.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in water
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    56296-78-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Eli Lilly and Company
Other Product-Specific Information:
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Fluoxetine hydrochloride include:

7 Citations: Showing 1 - 7
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  1. Functional integration of a serotonergic neuron in the Drosophila antennal lobe.
    Authors: Zhang and Gaudry
    Elife  2016;5
  2. Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation.
    Authors: Pai Et al.
    J Neurosci  2015;35:4366
  3. Serotonin receptors expressed in Drosophila mushroom bodies differentially modulate larval locomotion.
    Authors: Silva Et al.
    PLoS One  2014;9:e89641
  4. A translational rodent assay of affective biases in depression and antidepressant therapy.
    Authors: Stuart Et al.
    Neuropsychopharmacology  2013;38:1625
  5. HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity.
    Authors: Kurita Et al.
    Nat Neurosci  2012;15:1245
  6. TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells.
    Authors: Nozawa Et al.
    Proc Natl Acad Sci U S A  2009;106:3408
  7. Overexpression of the 5-hydroxytryptamine transporter gene: effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension.
    Authors: MacLean Et al.
    J Pharmacol Exp Ther  2004;109:2150

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