Selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a Ki
of 0.9 nmol/l and is between 150- and 900- fold selective over 5-HT1A
-adrenergic, and muscarinic receptors. Antidepressant. Induces differentiation of neuronal precursors, enhancing neuronal characteristics.
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All Tocris products are intended for laboratory research use only.
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Other Product-Specific Information:
Fluoxetine selectively alters 5-hydroxytryptamine1A and γ-aminobutyric acidB receptor-mediated hyperpolarization in area CA1, but not area CA3, hippocampal pyramidal cells.
Beck et al.
Fluoxetine. A review of its pharmacodynamic properties, and therapeutic efficacy in depressive illness.
Benfield et al.
Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.
Owens et al.
Increased cellular turnover in response to fluoxetine in neuronal precursors derived from human embryonic stem cells.
Chang et al.
The citations listed below are publications that use Tocris products. Selected citations for Fluoxetine hydrochloride include:
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