Fluoxetine hydrochloride

Tocris Bioscience | Catalog # 0927

5-HT reuptake inhibitor
Tocris Bioscience

Key Product Details

Description

5-HT reuptake inhibitor
View all 5-HT Transporter Inhibitors »

Product Description

Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a Ki of 0.9 nmol/l and is between 150- and 900-fold selective over 5-HT1A, 5-HT2A, H1, α1, α2-adrenergic, and muscarinic receptors. Antidepressant. Induces differentiation of neuronal precursors, enhancing neuronal characteristics. Fluoxetine also inhibits assembly and activation of the NLRP3-ASC inflammasome and prevents degeneration of retinal pigmented epithelium (RPE) cells in an animal model of dry age-related macular degeneration (AMD).

Licensing Information

Sold with the permission of Eli Lilly and Company

Product Specifications for Fluoxetine hydrochloride

Molecular Weight

345.78

Formula

C17H18F3NO.HCl

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

N-Methyl-3-[(4-trifluoromethyl)phenoxy]-3-phenylpropylamine hydrochloride

CAS Number

56296-78-7

PubChem ID

62857

InChI Key

GIYXAJPCNFJEHY-UHFFFAOYSA-N

SMILES

Cl.CNCCC(OC1=CC=C(C=C1)C(F)(F)F)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 3.46 10
DMSO 34.58 100

Preparing Stock Solutions for Fluoxetine hydrochloride

The following data is based on the product molecular weight 345.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.89 mL 14.46 mL 28.92 mL
5 mM 0.58 mL 2.89 mL 5.78 mL
10 mM 0.29 mL 1.45 mL 2.89 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

Calculators

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Product Documents for Fluoxetine hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Fluoxetine hydrochloride

For research use only

Citations for Fluoxetine hydrochloride

Customer Reviews for Fluoxetine hydrochloride (1)

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  • Fluoxetine decreases cued fear recall in c57bl6J mice
    Name: Olivia Hon
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 05/23/2019
    given 60 min before behavior, dissolved in.9% sterile saline
    10mg/kg fluoxetine hcl injected i.p. in male c57Bl6J mice before cued fear conditioning, significantly decreased freezing during fear recall 24 hours later
    Fluoxetine hydrochloride 0927

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