Catalog Number: 0927
Chemical Name: N-Methyl-3-[(4-trifluoromethyl)phenoxy]-3-phenylpropylamine hydrochloride
Biological Activity

Selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a Ki of 0.9 nmol/l and is between 150- and 900- fold selective over 5-HT1A, 5-HT2A, H1, α1, α2-adrenergic, and muscarinic receptors. Antidepressant. Induces differentiation of neuronal precursors, enhancing neuronal characteristics.

Deuterated analog also available.
Technical Data
  • M.Wt:
    345.78
  • Formula:
    C17H18F3NO.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in water
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    56296-78-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Eli Lilly and Company
Other Product-Specific Information:
Background References
  1. Fluoxetine selectively alters 5-hydroxytryptamine1A and γ-aminobutyric acidB receptor-mediated hyperpolarization in area CA1, but not area CA3, hippocampal pyramidal cells.
    Beck et al.
    J.Pharmacol.Exp.Ther., 1997;281:115
  2. Fluoxetine. A review of its pharmacodynamic properties, and therapeutic efficacy in depressive illness.
    Benfield et al.
    Drugs, 1986;32:481
  3. Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.
    Owens et al.
    J.Pharmacol.Exp.Ther., 1997;283:1305
  4. Increased cellular turnover in response to fluoxetine in neuronal precursors derived from human embryonic stem cells.
    Chang et al.
    Int.J.Dev.Biol., 2010;54:707
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Fluoxetine hydrochloride include:

3 Citations: Showing 1 - 3
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  1. Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation.
    Authors: Pai Et al.
    J Neurosci 2015;35:4366
  2. Serotonin receptors expressed in Drosophila mushroom bodies differentially modulate larval locomotion.
    Authors: Silva Et al.
    PLoS One 2014;9:e89641
  3. Overexpression of the 5-hydroxytryptamine transporter gene: effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension.
    Authors: MacLean Et al.
    J Pharmacol Exp Ther 2004;109:2150
Tocris Small Molecules
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Fluoxetine - d5 hydrochloride

5526 1  
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