Non-opioid analgesic with muscle relaxant properties. Activates KV
7 potassium channels, indirectly antagonizes NMDA receptors and modulates GABAA
receptors. Exhibits neuroprotective actions in a model of cerebral ischemia in mice and reduces apoptosis and necrosis induced by noxious stimuli.
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Other Product-Specific Information:
Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA antagonist.
Osborne et al.
The potassium channel modulator flupirtine shifts the frequency-response function of hippocampal synapses to favour LTD in mice.
Azad et al.
Molecular expression and pharmacological identification of a role for Kv7 channels in murine vascular reactivity.
Yeung et al.
Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine.