Chemical Name: N-[2-Amino-6-[[4-fluorophenyl)methyl]amino]-3-pyridinyl]carbamic acid ethyl ester maleate
Biological ActivityFlupirtine maleate is a non-opioid analgesic with muscle relaxant properties. Activates KV7 potassium channels, indirectly antagonizes NMDA receptors and modulates GABAA receptors. Exhibits neuroprotective actions in a model of cerebral ischemia in mice and reduces apoptosis and necrosis induced by noxious stimuli.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine.
Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA antagonist.
Osborne et al.
The potassium channel modulator flupirtine shifts the frequency-response function of hippocampal synapses to favour LTD in mice.
Azad et al.
Molecular expression and pharmacological identification of a role for Kv7 channels in murine vascular reactivity.
Yeung et al.
Citations for Flupirtine maleate
The citations listed below are publications that use Tocris products. Selected citations for Flupirtine maleate include:
2 Citations: Showing 1 - 2
Role of Kv7 channels in responses of the pulmonary circulation to hypoxia.
Authors: Sedivy Et al.
Am J Physiol Lung Cell Mol Physiol 2015;308:L48
Serum starvation-induced voltage-gated potassium channel Kv7.5 expression and its regulation by Sp1 in canine osteosarcoma cells.
Authors: Lee Et al.
Int J Mol Sci 2014;15:977
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Reviews for Flupirtine maleate
Average Rating: 5 (Based on 2 Reviews)
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Used flupirtine to understand how its analgesic effects correlate to its liver injury history. Flupirtine maleate dissloved easily in DMSO and worked nicely in experimental environment The product performed well under study conditions
The Flupirtine maleate worked excellent in study conditions and I would go back to this one everytime I need it. Flupirtine is a non-opioid non-analgesic drug prescribed in some European countries to treat post surgery patients for pain relief. My study involved investigating whether Flupirtine shows BK channel opening properties. Flupirtine works on SK channel and thus it can be speculated that it also works on BK channel to affect neuron excitability. I have used 4 different concentrations of the Flupirtine drug(0.1,1,10 and 100 microgram) to test on HEK 293 cells.NS1619 was used as a standard BK channel opener to compare its channel opening properties.