Flupirtine maleate

Catalog # Availability Size / Price Qty
2867/10
2867/50
Flupirtine maleate | CAS No. 75507-68-5 | Non-selective/Other Potassium Channel Activators
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Description: KV7 channel activator; also GABAA modulator and indirect NMDA antagonist
Alternative Names: D 9998

Chemical Name: N-[2-Amino-6-[[4-fluorophenyl)methyl]amino]-3-pyridinyl]carbamic acid ethyl ester maleate

Purity: ≥98%

Product Details
Citations (2)
Reviews (2)

Biological Activity

Non-opioid analgesic with muscle relaxant properties. Activates KV7 potassium channels, indirectly antagonizes NMDA receptors and modulates GABAA receptors. Exhibits neuroprotective actions in a model of cerebral ischemia in mice and reduces apoptosis and necrosis induced by noxious stimuli.

Technical Data

M.Wt:
420.4
Formula:
C15H17FN4O2.C4H4O4
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
75507-68-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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Citations for Flupirtine maleate

The citations listed below are publications that use Tocris products. Selected citations for Flupirtine maleate include:

2 Citations: Showing 1 - 2

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Reviews for Flupirtine maleate

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Flupirtine maleate effect on liver injury
By Sadequl Islam on 10/02/2018
Application: Species: Mouse

Used flupirtine to understand how its analgesic effects correlate to its liver injury history. Flupirtine maleate dissloved easily in DMSO and worked nicely in experimental environment The product performed well under study conditions


Flupirtine studied on HEK 293 cell line : Worked ideally on experiemental conditions
By Farzana Islam on 08/24/2018
Application: Species: Human

The Flupirtine maleate worked excellent in study conditions and I would go back to this one everytime I need it. Flupirtine is a non-opioid non-analgesic drug prescribed in some European countries to treat post surgery patients for pain relief. My study involved investigating whether Flupirtine shows BK channel opening properties. Flupirtine works on SK channel and thus it can be speculated that it also works on BK channel to affect neuron excitability. I have used 4 different concentrations of the Flupirtine drug(0.1,1,10 and 100 microgram) to test on HEK 293 cells.NS1619 was used as a standard BK channel opener to compare its channel opening properties.


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