Flupirtine maleate

Tocris Bioscience | Catalog # 2867

KV7 channel activator; also GABAA modulator and indirect NMDA antagonist
Tocris Bioscience

Key Product Details

Description

KV7 channel activator; also GABAA modulator and indirect NMDA antagonist

Alternative Names

D 9998
View all Non-selective/Other Potassium Channel Activators »

Product Description

Flupirtine maleate is a non-opioid analgesic with muscle relaxant properties. Activates KV7 potassium channels, indirectly antagonizes NMDA receptors and modulates GABAA receptors. Exhibits neuroprotective actions in a model of cerebral ischemia in mice and reduces apoptosis and necrosis induced by noxious stimuli.

Product Specifications for Flupirtine maleate

Molecular Weight

420.40

Formula

C15H17FN4O2.C4H4O4

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[2-Amino-6-[[4-fluorophenyl)methyl]amino]-3-pyridinyl]carbamic acid ethyl ester maleate

CAS Number

75507-68-5

PubChem ID

53276

InChI Key

JUUFBMODXQKSTD-UHFFFAOYSA-N

SMILES

OC(=O)\C=C/C(O)=O.NC1=C(NC(OCC)=O)C=CC(NCC2=CC=C(F)C=C2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.04 100
Ethanol 4.2 10

Preparing Stock Solutions for Flupirtine maleate

The following data is based on the product molecular weight 420.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.89 mL 23.79 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

Product Documents for Flupirtine maleate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Flupirtine maleate

For research use only

Related Research Areas

Ion Channels and Regulators

Citations for Flupirtine maleate

Customer Reviews for Flupirtine maleate (2)

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  • Flupirtine maleate effect on liver injury
    Name: Sadequl Islam
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 10/02/2018
    Used flupirtine to understand how its analgesic effects correlate to its liver injury history. Flupirtine maleate dissloved easily in DMSO and worked nicely in experimental environment The product performed well under study conditions
    Flupirtine maleate 2867
  • Flupirtine studied on HEK 293 cell line : Worked ideally on experiemental conditions
    Name: Farzana Islam
    Species: Human
    Cell Line/Tissue: HEK 293
    Verified Customer | Posted 08/24/2018
    Dissolve in sterile DMSO under hood if sterile Flupirtine is required.
    The Flupirtine maleate worked excellent in study conditions and I would go back to this one everytime I need it. Flupirtine is a non-opioid non-analgesic drug prescribed in some European countries to treat post surgery patients for pain relief. My study involved investigating whether Flupirtine shows BK channel opening properties. Flupirtine works on SK channel and thus it can be speculated that it also works on BK channel to affect neuron excitability. I have used 4 different concentrations of the Flupirtine drug(0.1,1,10 and 100 microgram) to test on HEK 293 cells.NS1619 was used as a standard BK channel opener to compare its channel opening properties.
    Flupirtine maleate 2867

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