Catalog Number: 2867
Alternate Names: D 9998
Chemical Name: N-[2-Amino-6-[[4-fluorophenyl)methyl]amino]-3-pyridinyl]carbamic acid ethyl ester maleate
Biological Activity
Non-opioid analgesic with muscle relaxant properties. Activates KV7 potassium channels, indirectly antagonizes NMDA receptors and modulates GABAA receptors. Exhibits neuroprotective actions in a model of cerebral ischemia in mice and reduces apoptosis and necrosis induced by noxious stimuli.

Deuterated analog also available.

Technical Data
  • M.Wt:
    420.4
  • Formula:
    C15H17FN4O2.C4H4O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    75507-68-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA antagonist.
    Osborne et al.
    Gen.Pharmacol., 1998;30:255
  2. The potassium channel modulator flupirtine shifts the frequency-response function of hippocampal synapses to favour LTD in mice.
    Azad et al.
    Neurosci.Lett., 2004;370:186
  3. Molecular expression and pharmacological identification of a role for Kv7 channels in murine vascular reactivity.
    Yeung et al.
    Br.J.Pharmacol., 2007;151:758
  4. Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine.
    Klinger
    Br.J.Pharmacol., 2012;166:1631
Tocris Small Molecules
Description Application Cat# Citations Images  

Flupirtine - d4 hydrochloride

5535  
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