Chemical Name: N-[2-Amino-6-[[4-fluorophenyl)methyl]amino]-3-pyridinyl]carbamic acid ethyl ester maleate
Biological ActivityFlupirtine maleate is a non-opioid analgesic with muscle relaxant properties. Activates KV7 potassium channels, indirectly antagonizes NMDA receptors and modulates GABAA receptors. Exhibits neuroprotective actions in a model of cerebral ischemia in mice and reduces apoptosis and necrosis induced by noxious stimuli.
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Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine.
Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA antagonist.
Osborne et al.
The potassium channel modulator flupirtine shifts the frequency-response function of hippocampal synapses to favour LTD in mice.
Azad et al.
Molecular expression and pharmacological identification of a role for Kv7 channels in murine vascular reactivity.
Yeung et al.
Citations for Flupirtine maleate
The citations listed below are publications that use Tocris products. Selected citations for Flupirtine maleate include:
2 Citations: Showing 1 - 2
Role of Kv7 channels in responses of the pulmonary circulation to hypoxia.
Authors: Sedivy Et al.
Am J Physiol Lung Cell Mol Physiol 2015;308:L48
Serum starvation-induced voltage-gated potassium channel Kv7.5 expression and its regulation by Sp1 in canine osteosarcoma cells.
Authors: Lee Et al.
Int J Mol Sci 2014;15:977
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