High affinity, selective glucocorticoid receptor agonist (K
= 0.5 nM). Potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC
= 3.7 nM)
. Inhibits mast cell accumulation in nasal mucosa following topical administration. Lipophilic anti-inflammatory agent with low oral bioavailability. Also potentiates K
1 channels (EC
= 37 nM).
25H 31F 3O 5S
Soluble to 50 mM in DMSO
Store at RT
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold for research purposes under agreement from GlaxoSmithKline
The anti-inflammatory profile of fluticasone propionate.
Enhancement of human eosinophil apoptosis by fluticasone propionate, budesonide, and beclomethasone.
Zhang et al.
Potentiation of the Kv1 family K + channel by cortisone analogues.
Pan et al.
ACS Chem.Biol., 2012;7:1641
In vitro glucocorticoid receptor binding and transcriptional activation by topically active glucocorticoids.
Smith and Kreutner
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