Chemical Name: (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid fluoromethyl ester
Biological ActivityFluticasone propionate is a high affinity, selective glucocorticoid receptor agonist (Kd = 0.5 nM). Potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC50 = 3.7 nM) in vitro. Inhibits mast cell accumulation in nasal mucosa following topical administration. Lipophilic anti-inflammatory agent with low oral bioavailability. Also potentiates KV1 channels (EC50 = 37 nM).
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Potentiation of the Kv1 family K+ channel by cortisone analogues.
Pan et al.
ACS Chem.Biol., 2012;7:1641
In vitro glucocorticoid receptor binding and transcriptional activation by topically active glucocorticoids.
Smith and Kreutner
The anti-inflammatory profile of flutic. propionate.
Enhancement of human eosinophil apoptosis by flutic. propionate, budesonide, and beclometh.
Zhang et al.
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