Fluticasone propionate

Catalog # Availability Size / Price Qty
2007/10
2007/50
Fluticasone propionate | CAS No. 80474-14-2 | Glucocorticoid Receptor Agonists
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Description: Selective high affinity glucocorticoid receptor agonist

Chemical Name: (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid fluoromethyl ester

Purity: ≥98%

Product Details
Reviews

Biological Activity

High affinity, selective glucocorticoid receptor agonist (Kd = 0.5 nM). Potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC50 = 3.7 nM) in vitro. Inhibits mast cell accumulation in nasal mucosa following topical administration. Lipophilic anti-inflammatory agent with low oral bioavailability. Also potentiates KV1 channels (EC50 = 37 nM).

Technical Data

M.Wt:
500.57
Formula:
C25H31F3O5S
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
80474-14-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline

Background References

  1. Potentiation of the Kv1 family K+ channel by cortisone analogues.
    Pan et al.
    ACS Chem.Biol., 2012;7:1641
  2. In vitro glucocorticoid receptor binding and transcriptional activation by topically active glucocorticoids.
    Smith and Kreutner
    Arzneim.-Forsch., 1998;48:956
  3. The anti-inflammatory profile of flutic. propionate.
    Johnson
    Allergy, 1995;50:11
  4. Enhancement of human eosinophil apoptosis by flutic. propionate, budesonide, and beclometh.
    Zhang et al.
    Eur.J.Pharmacol., 2000;406:325

Product Datasheets

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⚠ WARNING: This product can expose you to chemicals including Fluticasone propionate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

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