High affinity, selective glucocorticoid receptor agonist (Kd
= 0.5 nM). Potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC50
= 3.7 nM) in vitro
. Inhibits mast cell accumulation in nasal mucosa following topical administration. Lipophilic anti-inflammatory agent with low oral bioavailability. Also potentiates KV
1 channels (EC50
= 37 nM).
Soluble to 50 mM in DMSO
Store at RT
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The anti-inflammatory profile of fluticasone propionate.
Enhancement of human eosinophil apoptosis by fluticasone propionate, budesonide, and beclomethasone.
Zhang et al.
Potentiation of the Kv1 family K+ channel by cortisone analogues.
Pan et al.
ACS Chem.Biol., 2012;7:1641
In vitro glucocorticoid receptor binding and transcriptional activation by topically active glucocorticoids.
Smith and Kreutner