FSL 1

Tocris Bioscience | Catalog # 6011

TLR2/6 agonist (also a putative TLR10 ligand)
Tocris Bioscience
Discontinued Product
6011 has been discontinued. View all Toll-like Receptor Agonists products.

Key Product Details

Description

TLR2/6 agonist (also a putative TLR10 ligand)
View all Toll-like Receptor Agonists »

Product Description

FSL 1 is a TLR2/6 agonist (also a putative TLR10 ligand). Activates NF-κB. Induces pro-inflammatory cytokines including IL-8, IL-1β, CCL20 and TNF-α in vitro. Synergizes with IFNγ to induce CXCL10 release from melanoma cells.

Product Specifications for FSL 1

Molecular Weight

1666.16

Formula

C84H140N14O18S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

322455-70-9

PubChem ID

87858248

InChI Key

VJJLLNHELGKSNA-YWKNMTRCSA-N

SMILES

CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 2mg/ml in water

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for FSL 1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for FSL 1

For research use only

Customer Reviews for FSL 1 (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used FSL 1?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 1 of 1 review Showing All
Filter By:
Clear Filters X
  • FSL-1 works well for inducing TLR2 signaling
    Name: Xiaogang Wang
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: THP-1
    Verified Customer | Posted 09/15/2020
    We used this molecule to serve as a control to induce TLR2 signaling. The differentiated THP-1 macrophages were treated with FSL-1 for staphylococcus aureus lipoproteins for 4 h and the TNFa in culture supernatants was measured by ELISA.
    FSL 1 6011

There are no reviews that match your criteria.

Showing  1 - 1 of 1 review Showing All