FSL 1

Catalog # Availability Size / Price Qty
6011/100U
FSL 1
1 Image
Description: TLR2/6 agonist (also a putative TLR10 ligand)

Purity: ≥95%

Product Details
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Reviews (1)

Biological Activity

FSL 1 is a TLR2/6 agonist (also a putative TLR10 ligand). Activates NF-κB. Induces pro-inflammatory cytokines including IL-8, IL-1β, CCL20 and TNF-α in vitro. Synergizes with IFNγ to induce CXCL10 release from melanoma cells.

Technical Data

M.Wt:
1666.16
Formula:
C84H140N14O18S
Sequence:
CGDPKHPKSF

(Modifications: Cys-1 = S-[2,3-Bis(palmitoyloxy)-(2-R/S)propyl]-Cys)

Solubility:
Soluble to 2 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
322455-70-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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FSL-1 works well for inducing TLR2 signaling
By Xiaogang Wang on 09/15/2020
Application: Species: Human

We used this molecule to serve as a control to induce TLR2 signaling. The differentiated THP-1 macrophages were treated with FSL-1 for staphylococcus aureus lipoproteins for 4 h and the TNFa in culture supernatants was measured by ELISA.


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