FSL 1
Biological Activity
TLR2/6 agonist (also a putative TLR10 ligand). Activates NF-κB. Induces pro-inflammatory cytokines including IL-8, IL-1β, CCL20 and TNF-α in vitro. Synergizes with IFNγ to induce CXCL10 release from melanoma cells.Technical Data
(Modifications: Cys = S-[2,3-Bis(palmitoyloxy)-(2-R/S)propyl]-Cys)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6.
Okusawa et al.
Infect.Immun., 2004;72:1657 -
TLR2/6 agonists and IF.-gamma induce human melanoma cells to produce CXCL10.
Mauldin et al.
Int.J.Cancer, 2015;137:1386 -
Stable toll-like receptor 10 knockdown in THP-1 cells reduces TLR-ligand-induced proinflammatory cytokine expression.
Le et al.
Int.J.Mol.Sci., 2016;17:E859
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We used this molecule to serve as a control to induce TLR2 signaling. The differentiated THP-1 macrophages were treated with FSL-1 for staphylococcus aureus lipoproteins for 4 h and the TNFa in culture supernatants was measured by ELISA.
