Chemical Name: 4,4'-(2,5-Furandiyl)bis-benzenecarboximidamide dihydrochloride
Biological ActivityFuramidine dihydrochloride is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 9.4 μM). Exhibits selectivity over PRMT5, PRMT6 and CARM1 (IC50 values are 166, 283 and >400 μM respectively). Inhibits tyrosyl-DNA phosphodiesterase 1 (TDP-1) (IC50 = 1.2 μM). Inhibits cell proliferation in leukemia cell lines, suppresses neuroblastoma tumor growth, and reduces mis-splicing in in vitro and in vivo models of myotonic dystrophy type 1. Also shows dose-dependent inhibition of platelet aggregation (IC50 = 14.8 uM). Cell-permeable.
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Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
Yan et al.
Citations for Furamidine dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Furamidine dihydrochloride include:
3 Citations: Showing 1 - 3
A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer.
Authors: Tang Et al.
Cell Rep. 2022;38:110417
Inhibition of Arginine Methylation Impairs Platelet Function.
Authors: Marsden Et al.
ACS Pharmacol.Transl.Sci 2021;4:1567
Inhibiting Arginine Methylation as a Tool to Investigate Cross-Talk with Methylation and Acetylation Post-Translational Modifications in a Glioblastoma Cell Line.
Authors: Samuel Et al.
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