Selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50
= 9.4 μ
M). Exhibits selectivity over PRMT5, PRMT6 and CARM1 (IC50
values are 166, 283 and >400 μ
M respectively). Inhibits cell proliferation in leukemia cell lines. Cell-permeable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
Yan et al.