Catalog Number: 5202
Chemical Name: 4,4'-(2,5-Furandiyl)bis-benzenecarboximidamide dihydrochloride
Biological Activity
Selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 9.4 μM). Exhibits selectivity over PRMT5, PRMT6 and CARM1 (IC50 values are 166, 283 and >400 μM respectively). Inhibits cell proliferation in leukemia cell lines. Cell-permeable.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in water and to 50 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
    Yan et al.
    J.Med.Chem., 2014;57:2611
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