Chemical Name: 4,4'-(2,5-Furandiyl)bis-benzenecarboximidamide dihydrochloride
Biological ActivityFuramidine dihydrochloride is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 9.4 μM). Exhibits selectivity over PRMT5, PRMT6 and CARM1 (IC50 values are 166, 283 and >400 μM respectively). Inhibits cell proliferation in leukemia cell lines. Cell-permeable.
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Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
Yan et al.
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