Furamidine dihydrochloride

Catalog # Availability Size / Price Qty
Furamidine dihydrochloride | CAS No. 55368-40-6 | Protein Arginine Methyltransferase Inhibitors
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Description: Selective PRMT1 inhibitor

Chemical Name: 4,4'-(2,5-Furandiyl)bis-benzenecarboximidamide dihydrochloride

Purity: ≥98%

Product Details
Citations (3)

Biological Activity

Furamidine dihydrochloride is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 9.4 μM). Exhibits selectivity over PRMT5, PRMT6 and CARM1 (IC50 values are 166, 283 and >400 μM respectively). Inhibits tyrosyl-DNA phosphodiesterase 1 (TDP-1) (IC50 = 1.2 μM). Inhibits cell proliferation in leukemia cell lines, suppresses neuroblastoma tumor growth, and reduces mis-splicing in in vitro and in vivo models of myotonic dystrophy type 1. Also shows dose-dependent inhibition of platelet aggregation (IC50 = 14.8 uM). Cell-permeable.

Technical Data

Soluble to 50 mM in water and to 50 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
    Yan et al.
    J.Med.Chem., 2014;57:2611

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Citations for Furamidine dihydrochloride

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