Chemical Name: 4-[(2-Chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-6-carboxamide
Biological ActivityActivator of STING-dependent signaling; exhibits no direct binding affinity for STING. Stimulates IRF-3-induced transcription and induces IFNα and IFNγ gene expression in human fibroblasts. Exhibits no effect on NF-κB signaling. Blocks viral replication in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses.
Sali TM, Pryke KM, Abraham J et al.
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VersaClone cDNA Plasmids
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