Activator of STING-dependent signaling; exhibits no direct binding affinity for STING. Stimulates IRF-3-induced transcription and induces IFNα
gene expression in human fibroblasts. Exhibits no effect on NF-κ
B signaling. Blocks viral replication in vitro
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Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses.
Sali TM, Pryke KM, Abraham J et al.