Gabexate mesylate

Key Product Details

Product Description

Gabexate mesylate is a serine protease inhibitor; Gabexate mesylate inhibits trypsin, plasmin, plasma kallikrein and thrombin (IC₅₀ values are 9.4, 30, 41 and 110 μM respectively). Antithrombotic in vitro and in vivo. Gabexate mesylate also inhibits LPS-induced TNF-α production, probably by inhibiting NF-κB and AP-1 activation. Gabexate mesylate attenuates allergen-induced airway inflammation and eosinophils infiltration in the lung of asthma murine model.

Product Specifications for Gabexate mesylate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Gabexate mesylate

The following data is based on the product molecular weight 417.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.40 mL	11.98 mL	23.95 mL
5 mM	0.48 mL	2.40 mL	4.79 mL
10 mM	0.24 mL	1.20 mL	2.40 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Chen Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen induced airway inflammation and eosinophilia in a murine model of asthma. J.Allergy Clin.Immunol. 2006 PMID:  16815145
• Yuksel Gabexate mesilate, a synthetic protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-α production by inhibiting activation of both nuclear factor-κB and activator protein-1 in human monocytes. J.Pharmacol.Exp.Ther. 2003 PMID: 12649382
• Ohno FOY: [Ethyl p-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine proteinase inhibitor. II. In vivo effect on coagulo-fibrinolytic system in comparison with he. or apro. Thromb.Res. 1981 PMID: 6178174
• Tamura Synthetic inhibitors of trypsin, plasmin, kallikrein, thrombin, C_1r and C₁ esterase. Biochim.Biophys.Acta 1977 PMID: 143965
• Ohno FOY: [Ethyl p-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine proteinase inhibitor. I. Inhibition of thrombin and factor Xa in vitro. Thromb.Res. 1980 PMID: 6449757

Product Documents for Gabexate mesylate