Chemical Name: 4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef]benzazepin-6-ol hydrobromide
Biological ActivityLong-acting, centrally active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Galantamine prevents apoptosis induced by β-amyloid and thapsigargin: involvement of nicotinic acetycholine receptors.
Arias et al.
Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice.
Capsoni et al.
The pharmacology of galanthamine and its analogues.
Galanthamine, an acetylcholinesterase inhibitor: a time course of the effects on performance and neurochemical parameters in mice.
Sweeney et al.
Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors.
Samochocki et al.
Citation for Galanthamine hydrobromide
The citations listed below are publications that use Tocris products. Selected citations for Galanthamine hydrobromide include:
1 Citation: Showing 1 - 1
Galantamine improves olfactory learning in the Ts65Dn mouse model of Down syndrome.
Authors: Souza Et al.
Sci Rep 2012;1:137
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