Galnon

Catalog # Availability Size / Price Qty
2085/10
Galnon
1 Image
Description: Non-selective galanin receptor agonist

Chemical Name: 3-Cyclohexyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-lysinamide

Product Details
Citations (1)
Supplemental Products
Reviews

Biological Activity

Novel non-peptide galanin GAL1 and GAL2 receptor agonist (Ki values are 11.7 and 34.1 μM respectively). Stimulates insulin release in isolated pancreatic islets from normal and diabetic rats. Systemically active in vivo; displays anticonvulsant activity following i.p. administration in mice. Central and peripheral administration also transiently inhibits food intake in rats and mice.

Technical Data

M.Wt:
678.83
Formula:
C40H46N4O6
Sequence:
AK

(Modifications: Ala-1 = Fmoc-β-cyclohexyl-Ala, Lys-2 = Lys-(4-methyl-2-oxo-2H-1-benzopyran)

Solubility:
Soluble to 67.88 mg/ml in DMSO and to 16.97 mg/ml in ethanol with gentle warming
Storage:
Desiccate at -20°C
CAS No:
475115-35-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Regulation of feeding by galnon.
    Abramov et al.
    Neuropeptides, 2004;38:55
  2. Anticonvulsant activity of a nonpeptide galanin receptor agonist
    Saar et al.
    Proc.Natl.Acad.Sci.USA, 2002;99:7136
  3. A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus.
    Lu et al.
    Proc.Natl.Acad.Sci., 2005;102:874
  4. Effects of galnon, a non-peptide galanin-receptor agonist, on Ins release from rat pancreatic islets.
    Quynh et al.
    Biochem.Biophys.Res.Comm., 2005;328:213

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citation for Galnon

The citations listed below are publications that use Tocris products. Selected citations for Galnon include:

1 Citation: Showing 1 - 1

FAQs

No product specific FAQs exist for this product, however you may

View all Peptide FAQs

Reviews for Galnon

There are currently no reviews for this product. Be the first to review Galnon and earn rewards!

Have you used Galnon?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.