Galnon
Chemical Name: 3-Cyclohexyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-lysinamide
Biological Activity
Galnon is a novel non-peptide galanin GAL1 and GAL2 receptor agonist (Ki values are 11.7 and 34.1 μM respectively). Stimulates insulin release in isolated pancreatic islets from normal and diabetic rats. Systemically active in vivo; displays anticonvulsant activity following i.p. administration in mice. Central and peripheral administration also transiently inhibits food intake in rats and mice.Technical Data
(Modifications: Ala-1 = Fmoc-β-cyclohexyl-Ala, Lys-2 = Lys-(4-methyl-2-oxo-2H-1-benzopyran)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Regulation of feeding by galnon.
Abramov et al.
Neuropeptides, 2004;38:55 -
Anticonvulsant activity of a nonpeptide galanin receptor agonist
Saar et al.
Proc.Natl.Acad.Sci.USA, 2002;99:7136 -
A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus.
Lu et al.
Proc.Natl.Acad.Sci., 2005;102:874 -
Effects of galnon, a non-peptide galanin-receptor agonist, on Ins release from rat pancreatic islets.
Quynh et al.
Biochem.Biophys.Res.Comm., 2005;328:213
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Citation for Galnon
The citations listed below are publications that use Tocris products. Selected citations for Galnon include:
1 Citation: Showing 1 - 1
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Galanin-induced decreases in nucleus accumbens/striatum excitatory postsynaptic potentials and mor. conditioned place preference require both galanin receptor 1 and galanin receptor 2.
Authors: Einstein Et al.
Eur J Neurosci 2013;37:1541
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