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Description: Non-selective galanin receptor agonist

Chemical Name: 3-Cyclohexyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-lysinamide

Product Details
Citations (1)

Biological Activity

Galnon is a novel non-peptide galanin GAL1 and GAL2 receptor agonist (Ki values are 11.7 and 34.1 μM respectively). Stimulates insulin release in isolated pancreatic islets from normal and diabetic rats. Systemically active in vivo; displays anticonvulsant activity following i.p. administration in mice. Central and peripheral administration also transiently inhibits food intake in rats and mice.

Technical Data


(Modifications: Ala-1 = Fmoc-β-cyclohexyl-Ala, Lys-2 = Lys-(4-methyl-2-oxo-2H-1-benzopyran)

Soluble to 67.88 mg/ml in DMSO and to 16.97 mg/ml in ethanol with gentle warming
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Regulation of feeding by galnon.
    Abramov et al.
    Neuropeptides, 2004;38:55
  2. Anticonvulsant activity of a nonpeptide galanin receptor agonist
    Saar et al.
    Proc.Natl.Acad.Sci.USA, 2002;99:7136
  3. A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus.
    Lu et al.
    Proc.Natl.Acad.Sci., 2005;102:874
  4. Effects of galnon, a non-peptide galanin-receptor agonist, on Ins release from rat pancreatic islets.
    Quynh et al.
    Biochem.Biophys.Res.Comm., 2005;328:213

Product Datasheets

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for Galnon

The citations listed below are publications that use Tocris products. Selected citations for Galnon include:

1 Citation: Showing 1 - 1


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