Catalog Number: 2085
Chemical Name: 3-Cyclohexyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-lysinamide
Biological Activity
Novel non-peptide galanin GAL1 and GAL2 receptor agonist (Ki values are 11.7 and 34.1 μM respectively). Stimulates insulin release in isolated pancreatic islets from normal and diabetic rats. Systemically active in vivo; displays anticonvulsant activity following i.p. administration in mice. Central and peripheral administration also transiently inhibits food intake in rats and mice.
Technical Data
  • M.Wt:
    678.83
  • Formula:
    C40H46N4O6
  • Sequence:
    AK

    (Modifications: Ala-1 = Fmoc-β-cyclohexyl-Ala, Lys-2 = Lys-(4-methyl-2-oxo-2H-1-benzopyran)

  • Solubility:
    Soluble to 67.88 mg/ml in DMSO and to 16.97 mg/ml in ethanol with gentle warming
  • Storage:
    Desiccate at -20°C
  • CAS No:
    475115-35-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Regulation of feeding by galnon.
    Abramov et al.
    Neuropeptides, 2004;38:55
  2. Anticonvulsant activity of a nonpeptide galanin receptor agonist
    Saar et al.
    Proc.Natl.Acad.Sci.USA, 2002;99:7136
  3. A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus.
    Lu et al.
    Proc.Natl.Acad.Sci., 2005;102:874
  4. Effects of galnon, a non-peptide galanin-receptor agonist, on insulin release from rat pancreatic islets.
    Quynh et al.
    Biochem.Biophys.Res.Comm., 2005;328:213

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