Catalog Number: 3191
Chemical Name: 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine
Biological Activity
GLI antagonist that inhibits GLI1 and GLI2-induced transcription (IC50 ~ 5 μM). Inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo. Inhibits the pluripotency factors Oct4, Sox-2, Nanog and c-Myc in pancreatic cancer stem cells.
Technical Data
  • M.Wt:
    429.61
  • Formula:
    C27H35N5
  • Solubility:
    Soluble to 50 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    500579-04-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells.
    Mazumdar T, Devecchio J, Agyeman A et al.
    Cancer Res.
  2. GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft.
    Fu et al.
    Cancer Lett., 2012;330:22
  3. Inhibition of GLI-mediated transcription and tumor cell growth by small molecule antagonists.
    Lauth et al.
    Proc.Natl.Acad.Sci.USA, 2007;104:8455
Citations:

The citations listed below are publications that use Tocris products. Selected citations for GANT 61 include:

1 Citations: Showing 1 - 1

  1. Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis.
    Authors: Lim Et al.
    Oncotarget 2015;6:1519

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