GANT 61

  ( 4 citations )    
Product Datasheet
Catalog Number:3191
Chemical Name:2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine
Product Details
Citations (4)
Reviews
Biological Activity
GLI antagonist that inhibits GLI1 and GLI2-induced transcription (IC50 ~ 5 μM). Inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo. Inhibits the pluripotency factors Oct4, Sox-2, Nanog and c-Myc in pancreatic cancer stem cells.
Technical Data
  • M.Wt:
    429.61
  • Formula:
    C27H35N5
  • Solubility:
    Soluble to 50 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    500579-04-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for GANT 61 include:

4 Citations: Showing 1 - 4
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  1. Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells.
    Authors: Oladapo
    Cancer Lett  2017;411:136
  2. Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis.
    Authors: Lim Et al.
    Oncotarget  2015;6:1519
  3. Expression of Hedgehog Pathway Mediator GLI Represents a Negative Prognostic Marker in Human Acute Myeloid Leukemia and Its Inhibition Exerts Antileukemic Effects.
    Authors: Wellbrock Et al.
    Clin Cancer Res  2015;21:2388
  4. Hedgehog signaling stimulates the formation of proliferating Müller glia-derived progenitor cells in the chick retina.
    Authors: Todd and Fischer
    Development  2015;142:2610

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