Biological ActivityGap19 is a selective connexin 43 (Cx43) hemichannel blocker; has no effect on gap junction coupling or Panx-1 channels. Reduces mitochondrial potassium influx in cardiomyocytes and attenuates glutamate-triggered ATP release in primary astrocytes. Modestly reduces infarct size in a mouse ischemia model.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes.
Abudara et al.
Connexin 43 impacts on mitochondrial potassium uptake.
Boengler et al.
Front Pharmacol., 2013;4
Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury.
Wang et al.
Basic Res.Cardiol., 2013;108:309
Citations for Gap19
The citations listed below are publications that use Tocris products. Selected citations for Gap19 include:
3 Citations: Showing 1 - 3
Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma.
Authors: Best Et al.
Nat Commun 2019;10:4190
Inhibition of Connexin 43 Hemichannels Alleviates Cerebral Ischemia/Reperfusion Injury via the TLR4 Signaling Pathway.
Authors: Chen Et al.
Front Cell Neurosci 2018;12:372
Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis.
Authors: Almad Et al.
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