Catalog Number: 5353
Biological Activity
Selective connexin 43 (Cx43) hemichannel blocker; has no effect on gap junction coupling or Panx-1 channels. Reduces mitochondrial potassium influx in cardiomyocytes and attenuates glutamate-triggered ATP release in primary astrocytes. Modestly reduces infarct size in a mouse ischemia model.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:
  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury.
    Wang et al.
    Basic Res.Cardiol., 2013;108:309
  2. Connexin 43 impacts on mitochondrial potassium uptake.
    Boengler et al.
    Front Pharmacol., 2013;4
  3. The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes.
    Abudara et al.
    Front Cell Neurosci., 2014;8
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