GCH1 Antibody

Novus Biologicals | Catalog # NBP1-20923

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all GCH1 Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-GKVHIGYLPNKQ corresponding to internal region according to NP_001019195.1, NP_001019241.1, NP_001019242.1.

Epitope

C terminus

Specificity

This antibody is expected to recognize all four isoforms (NP_000152.1 ; NP_001019195.1 ; NP_001019241.1 ; NP_001019242.1)

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for GCH1 Antibody

Immunohistochemistry: GCH1 Antibody [NBP1-20923]

Immunohistochemistry: GCH1 Antibody [NBP1-20923]

Immunohistochemistry: GCH1 Antibody [NBP1-20923] - (5ug/ml) staining of paraffin embedded Human Small Intestine. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
GCH1 Antibody [NBP1-20923] - (5ug/ml) staining of paraffin embedded Human Cerebellum. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for GCH1 Antibody

Application
Recommended Usage

Immunohistochemistry

5 ug/ml

Immunohistochemistry-Paraffin

5 ug/ml

Peptide ELISA

Detection limit 1:16000

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: GCH1

This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.

Long Name

GTP Cyclohydrolase 1

Alternate Names

DYT5, DYT5a, GTP-CH-1, GTP-CH-I, GTPCH1

Entrez Gene IDs

2643 (Human); 14528 (Mouse); 29244 (Rat)

Gene Symbol

GCH1

UniProt

NP_000152.1 (Human)

Additional GCH1 Products

Product Documents for GCH1 Antibody

Certificate of Analysis

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Product Specific Notices for GCH1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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