GI 530159

Key Product Details

Product Description

GI 530159 is a TREK1 and TREK2 channel activator (EC₅₀ = 0.76 μM in Rb efflux assay in TREK1-expressing CHO cells). Exhibits selectivity for TREK1/2 over TRAAK, TASK3 and a range of other potassium channels. Hyperpolarizes membrane potential of dorsal root ganglion neurons and depresses neuronal activity in vitro.

Product Specifications for GI 530159

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GI 530159

The following data is based on the product molecular weight 518.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.93 mL	9.64 mL	19.29 mL
5 mM	0.39 mL	1.93 mL	3.86 mL
10 mM	0.19 mL	0.96 mL	1.93 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Loucif GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K_2P) channel opener, reduces rat dorsal root ganglion neuron excitability. Br.J.Pharmacol. 2018 PMID: 29150838

Product Documents for GI 530159