Ginkgolic Acid
Chemical Name: 2-Hydroxy-6-(8Z)-8-pentadecenylbenzoic acid
Purity: ≥97%
Biological Activity
Ginkgolic Acid is an inhibitor of SUMOylation (IC50 = 3 μM). Directly binds E1 and inhibits formation of E1-SUMO intermediate. Protects against amyloid β-induced impairment of neurotransmission and synaptic plasticity. Also suppresses CD44 and MMP14 expression in breast cancer cells, eliminating cancer stem cells and inhibiting tumorigenesis.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate.
Fukuda et al.
Chem.Biol., 2009;16:133 -
Ginkgolic acid protects against Aβ-induced synaptic dysfunction in the hippocampus.
Mango et al.
Front.Pharmacol., 2016;7:401 -
Inhibiting the SUMO pathway represses the cancer stem cell population in breast and colorectal carcinomas.
Bogachek et al.
Stem Cell Reports., 2016;7:1140
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