Ginkgolic Acid

Key Product Details

Product Description

Ginkgolic Acid is an inhibitor of SUMOylation (IC₅₀ = 3 μM). Directly binds E1 and inhibits formation of E1-SUMO intermediate. Protects against amyloid β-induced impairment of neurotransmission and synaptic plasticity. Also suppresses CD44 and MMP14 expression in breast cancer cells, eliminating cancer stem cells and inhibiting tumorigenesis.

Product Specifications for Ginkgolic Acid

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Ginkgolic Acid

The following data is based on the product molecular weight 346.50.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.89 mL	14.43 mL	28.86 mL
5 mM	0.58 mL	2.89 mL	5.77 mL
10 mM	0.29 mL	1.44 mL	2.89 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Mango Ginkgolic acid protects against Aβ-induced synaptic dysfunction in the hippocampus. Front.Pharmacol. 2016 PMID:  27833555
• Bogachek Inhibiting the SUMO pathway represses the cancer stem cell population in breast and colorectal carcinomas. Stem Cell Reports. 2016 PMID: 27916539
• Fukuda Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate. Chem.Biol. 2009 PMID: 19246003

Product Documents for Ginkgolic Acid