Girdin (GIRDers of actIN filaments; also APE and GIV) is a member of the CCDC88 family of molecules. It is a cytosolic protein, ubiquitously expressed, and plays a key role in the motility of breast cancer cells. Human Girdin is 1871 amino acids (aa) in length. It contains two coiled-coil regions that mediate homodimerization (aa 196-425 and 458-1358), and one phosphoinositide-binding domain (aa 1390-1408). Normally, Girdin is membrane-associated via an interaction with phosphoinositides. Upon phosphorylation at Ser1417 by Akt, it relocates to lamellipodia where it crosslinks actin filaments. Multiple isoforms of Girdin have been detected.
Girdin Antibody Blocking Peptide
Novus Biologicals | Catalog # NBP1-76253PEP
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Key Product Details
Source
Synthetic
Applications
Antibody Competition
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Product Specifications
Description
A blocking peptide containing 16 amino acids near the carboxy terminus of human Girdin.
Source: Synthetic
(Accession #: NP_060554)
Application Notes
This peptide is useful as a blocking peptide for NBP1-76253.
For further blocking peptide related protocol, click here.
For further blocking peptide related protocol, click here.
Protein / Peptide Type
Antibody Blocking Peptide
Formulation, Preparation, and Storage
NBP1-76253PEP
| Formulation | PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin. |
| Preservative | 0.02% Sodium Azide |
| Concentration | 0.2 mg/ml |
| Shipping | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Store at -20C. Avoid freeze-thaw cycles. |
Background: Girdin
Long Name
Girders of Actin Filament
Alternate Names
APE, CCDC88A, GIV, GRDN, HkRP1
Gene Symbol
CCDC88A
Additional Girdin Products
Product Documents for Girdin Antibody Blocking Peptide
Certificate of Analysis
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Product Specific Notices for Girdin Antibody Blocking Peptide
This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.
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