Catalog Number: 5133
Chemical Name: 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino-3-pyridinecarboxylic acid
Biological Activity
Potent glucokinase activator (EC50 = 33 nM). Significantly reduces plasma glucose levels in diabetic rats; stimulates insulin release from mouse islets of Langerhans.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats.
    Coope et al.
    Br.J.Pharmacol., 2006;149:328
  2. Glucokinase activators: molecular tools for studying the physiology of insulin-secreting cells.
    Johnson et al.
    Biochem.Soc.Trans., 2007;35:1208
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