Glibenclamide

Tocris Bioscience | Catalog # 0911

Kir6 (KATP) channel blocker
Tocris Bioscience

Key Product Details

Description

Kir6 (KATP) channel blocker

Alternative Names

Glyburide
View all Inward Rectifier Potassium Channel Blockers »

Product Description

Glibenclamide is an ATP-dependent K+ channel (Kir6, KATP) and CFTR Cl- channel blocker. Inhibits Kir6 currents in the pancreas, by binding to the SUR1 regulatory subunit, causing an increase in intracellular Ca2+ and insulin secretion. Inhibits recombinant CFTR Cl- channels with an IC50 of 20 μM.

Product Specifications for Glibenclamide

Molecular Weight

494.00

Formula

C23H28ClN3O5S

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

5-Chloro-N-[2-[4-[[[(Cylcohexylamino)carbonyl]amino]sulphonyl]phenyl]ethyl]-2-methoxybenzamide

CAS Number

10238-21-8

PubChem ID

3488

InChI Key

ZNNLBTZKUZBEKO-UHFFFAOYSA-N

SMILES

COC1=C(C=C(Cl)C=C1)C(=O)NCCC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100
Ethanol 5

Preparing Stock Solutions for Glibenclamide

The following data is based on the product molecular weight 494.00.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.02 mL 10.12 mL 20.24 mL
5 mM 0.40 mL 2.02 mL 4.05 mL
10 mM 0.20 mL 1.01 mL 2.02 mL
50 mM 0.04 mL 0.20 mL 0.40 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 118 publications citing the usage of this product.

Product Documents for Glibenclamide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Glibenclamide

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for Glibenclamide (2)

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  • Glibenclamide prolongs action potential duration in LPS-treated cardiomyocytes
    Name: Anonymous
    Species: Guinea Pig
    Assay Type: In Vitro
    Cell Line/Tissue: Ventricular cardiomyocytes
    Verified Customer | Posted 01/22/2019
    Primary guinea pig ventricular cardiomyocytes were incubated with LPS for 6-10 h. Cells were patched and stimulated at a 1 Hz frequency. Action potentials were recorded before and after glibenclamide (5 microM) containing normal tyrode solution. Glibenclamide prolonged action potential duration in LPS-treated cardiomyocytes; indicating role of KATP channels.
    Glibenclamide 0911
  • Glibenclamide was used to study combination drug effect with B blockers
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 10/29/2018
    Glibenclamide was used in our lab to study combination drug effect. Beta blocker and glibenclamide was administered in combination and separately to study their pattern of action over blood glucose level.
    Glibenclamide 0911

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