Catalog Number: 0911
Alternate Names: Glyburide
Chemical Name: 5-Chloro-N-[2-[4-[[[(Cylcohexylamino)carbonyl]amino]sulphonyl]phenyl]ethyl]-2-methoxybenzamide
Biological Activity
ATP-dependent K+ channel (Kir6, KATP) and CFTR Cl- channel blocker. Inhibits Kir6 currents in the pancreas, causing an increase in intracellular Ca2+ and insulin secretion. Inhibits recombinant CFTR Cl- channels with an IC50 of 20 μM.
Technical Data
  • M.Wt:
    494
  • Formula:
    C23H28ClN3O5S
  • Solubility:
    Soluble to 100 mM in DMSO and to 5 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    10238-21-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Glibenclamide: a review.
    Brogden et al.
    Drugs, 1979;18:329
  2. Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride channels.
    Sheppard and Welsh
    J.Gen.Physiol., 1992;100:573
  3. Potassium channel modulators: scientific applications and therapeutic promise.
    Robertson et al.
    J.Med.Chem., 1990;33:1529
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Glibenclamide include:

11 Citations: Showing 1 - 10
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  1. Antidiarrhoeal, antisecretory and antispasmodic activities of Matricaria chamomilla are mediated predominantly through K(+)-channels activation.
    Authors: Mehmood Et al.
    Neuroscience 2015;15:75
  2. Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments.
    Authors: Fransen Et al.
    Biomed Res Int 2015;10:e0121634
  3. Regulation of neurons in the dorsal motor nucleus of the vagus by SIRT1.
    Authors: Jiang and Zsombok
    Front Neurosci 2014;7:270
  4. Characterization of imidazoline receptors in blood vessels for the development of antihypertensive agents.
    Authors: Chen Et al.
    J Pharmacol Exp Ther 2014;2014:182846
  5. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes.
    Authors: Seto Et al.
    J Neurophysiol 2013;8:e66404
  6. Activation of peripheral δ-opioid receptors leads to anti-hyperalgesic responses in the masseter muscle of male and female rats.
    Authors: Saloman Et al.
    PLoS One 2011;190:379
  7. The acute antinociceptive effect of HBO2 is mediated by a NO-cyclic GMP-PKG-KATP channel pathway in mice.
    Authors: Quock Et al.
    Brain Res 2011;1368:102
  8. Expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat.
    Authors: Chung Et al.
    J Korean Med Sci 2011;106:2865
  9. Polyphenol (-)-epigallocatechin gallate during ischemia limits infarct size via mitochondrial K(ATP) channel activation in isolated rat hearts.
    Authors: Song Et al.
    PLoS One 2010;25:380
  10. Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome.
    Authors: He Et al.
    J Immunol 2010;184:5743
  11. Nesfatin-1 inhibits NPY neurons in the arcuate nucleus.
    Authors: Price Et al.
    Brain Res 2008;1230:99
Expand to show all 11 Citations

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