Chemical Name: (2R)-N4-Hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide
Biological ActivityGM 6001 is a broad spectrum MMP inhibitor. Reduces infarct volume following middle cerebral artery occlusion in an ischemic mouse model. Also inhibits human skin fibroblast collagenase (Ki = 0.4 nM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Involvement of matrix metalloproteinase-mediated proteolysis of neural cell adhesion molecule in the development of cerebral ischemic neuronal damage.
Shichi et al.
Inhibition of skin fibroblast Col., thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids.
Grobelny et al.
Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells.
Chao et al.
Citations for GM 6001
The citations listed below are publications that use Tocris products. Selected citations for GM 6001 include:
10 Citations: Showing 1 - 10
Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease.
Authors: Kim Et al.
Nat Commun 2018;9:4600
Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis.
Authors: Luo Et al.
Nat Commun 2018;9:4126
ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation.
Cell Death Dis 2017;8:e2622
Up-Regulated Expression of Matrix Metalloproteinases in Endothelial Cells Mediates Platelet Microvesicle-Induced Angiogenesis.
Authors: Sun Et al.
Cell Physiol Biochem 2017;41:2319
Matrix metalloproteinase activity stimulates N-cadherin shedding and the soluble N-cadherin ectodomain promotes classical microglial activation.
Authors: Conant Et al.
J Neuroinflammation 2017;14:56
Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function.
Authors: Lahey Et al.
PLoS One 2017;12:e0180259
TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion.
Authors: Bras Et al.
PLoS One 2015;330:29
PRL-3 mediates the protein maturation of ULBP2 by regulating the tyrosine phosphorylation of HSP60.
Authors: Leung Et al.
J Immunol 2015;194:2930
CD40-TRAF Signaling Upregulates CX3CL1 and TNF-α in Human Aortic Endothelial Cells but Not in Retinal Endothelial Cells.
Authors: Greene Et al.
Proc Natl Acad Sci U S A 2015;10:e0144133
STAT induce Ins-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway.
Authors: Son Et al.
Mol Neurodegener 2015;10:56
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