Catalog Number: 2983
Alternate Names: Galardin, Ilomastat
Chemical Name: (2R)-N4-Hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide
Biological Activity
Broad spectrum MMP inhibitor. Reduces infarct volume following middle cerebral artery occlusion in an ischemic mouse model. Also inhibits human skin fibroblast collagenase (Ki = 0.4 nM).
Technical Data
  • M.Wt:
    388.46
  • Formula:
    C20H28N4O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >95%
  • Storage:
    Store at -20°C
  • CAS No:
    142880-36-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Involvement of matrix metalloproteinase-mediated proteolysis of neural cell adhesion molecule in the development of cerebral ischemic neuronal damage.
    Shichi et al.
    J.Pharmacol.Exp.Ther., 2011;338:701
  2. Inhibition of skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids.
    Grobelny et al.
    Biochemistry, 1992;31:7152
  3. Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells.
    Chao et al.
    Eur.J.Pharmacol., 2007;573:49
Citations:

The citations listed below are publications that use Tocris products. Selected citations for GM 6001 include:

4 Citations: Showing 1 - 4
Filter your results:

  1. ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation.
    Authors: Schumacher
    Cell Death Dis 2017;8:e2622
  2. TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion.
    Authors: Bras Et al.
    PLoS One 2015;330:29
  3. CD40-TRAF Signaling Upregulates CX3CL1 and TNF-α in Human Aortic Endothelial Cells but Not in Retinal Endothelial Cells.
    Authors: Greene Et al.
    Proc Natl Acad Sci U S A 2015;10:e0144133
  4. Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway.
    Authors: Son Et al.
    Mol Neurodegener 2015;10:56

Have you used GM 6001?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information