GM 6001

  ( 6 citations )    
Product Datasheet
Catalog Number:2983
Alternate Names:Galardin, Ilomastat
Chemical Name:(2R)-N4-Hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide
Product Details
Citations (6)
Reviews
Biological Activity
Broad spectrum MMP inhibitor. Reduces infarct volume following middle cerebral artery occlusion in an ischemic mouse model. Also inhibits human skin fibroblast collagenase (Ki = 0.4 nM).
Technical Data
  • M.Wt:
    388.46
  • Formula:
    C20H28N4O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >95
  • Storage:
    Store at -20°C
  • CAS No:
    142880-36-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for GM 6001 include:

6 Citations: Showing 1 - 6
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  1. ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation.
    Authors: Schumacher
    Cell Death Dis  2017;8:e2622
  2. Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function.
    Authors: Lahey Et al.
    PLoS One  2017;12:e0180259
  3. TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion.
    Authors: Bras Et al.
    PLoS One  2015;330:29
  4. PRL-3 mediates the protein maturation of ULBP2 by regulating the tyrosine phosphorylation of HSP60.
    Authors: Leung Et al.
    J Immunol  2015;194:2930
  5. CD40-TRAF Signaling Upregulates CX3CL1 and TNF-α in Human Aortic Endothelial Cells but Not in Retinal Endothelial Cells.
    Authors: Greene Et al.
    Proc Natl Acad Sci U S A  2015;10:e0144133
  6. Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway.
    Authors: Son Et al.
    Mol Neurodegener  2015;10:56

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