GMB 475

Key Product Details

Product Description

GMB 475 is a BCR-ABL1 kinase PROTAC^® Degrader. Induces degradation of BCR-ABL1 and cABL1, inhibits downstream STAT5 signaling and suppresses cell proliferation in chronic myeloid leukemia cells lines.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for GMB 475

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GMB 475

The following data is based on the product molecular weight 861.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.16 mL	5.80 mL	11.60 mL
5 mM	0.23 mL	1.16 mL	2.32 mL
10 mM	0.12 mL	0.58 mL	1.16 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Burslem Targeting BCR-ABL1 in chronic myeloid leukemia by PROTAC-mediated targeted protein degradation. Cancer Res 2019 PMID: 31311809

Product Documents for GMB 475