Selective opener of acid-sensing ion channel 3 (ASIC3) at pH 7.4. Alters the pH dependence of ASIC1a and ASIC1b; does not affect the activation curve of ASIC2a.
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Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline.
Alijevic and Kellenberger
ASIC3 channels integrate agmatine and multiple inflammatory signals through the nonproton ligand sensing domain.
Li et al.