Catalog Number: 5028
Chemical Name: N-(4-Methyl-2-quinazolinyl)-guanidine hydrochloride
Biological Activity
Selective opener of acid-sensing ion channel 3 (ASIC3) at pH 7.4. Alters the pH dependence of ASIC1a and ASIC1b; does not affect the activation curve of ASIC2a.
Technical Data
  • M.Wt:
    237.69
  • Formula:
    C10H11N5.HCl
  • Solubility:
    Soluble to 50 mM in DMSO and to 5 mM in water with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    5361-15-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline.
    Alijevic and Kellenberger
    J.Biol.Chem., 2012;287:36059
  2. ASIC3 channels integrate agmatine and multiple inflammatory signals through the nonproton ligand sensing domain.
    Li et al.
    Mol.Pain, 2010;6:88

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