GMQ hydrochloride

Key Product Details

Product Description

GMQ hydrochloride is a selective opener of acid-sensing ion channel 3 (ASIC3) at pH 7.4. Alters the pH dependence of ASIC1a and ASIC1b; does not affect the activation curve of ASIC2a.

Product Specifications for GMQ hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GMQ hydrochloride

The following data is based on the product molecular weight 237.69.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	8.41 mL	42.07 mL	84.14 mL
2.5 mM	1.68 mL	8.41 mL	16.83 mL
5 mM	0.84 mL	4.21 mL	8.41 mL
25 mM	0.17 mL	0.84 mL	1.68 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Li ASIC3 channels integrate agmatine and multiple inflammatory signals through the nonproton ligand sensing domain. Mol.Pain 2010 PMID: 21143836
• Alijevic and Kellenberger Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline. J.Biol.Chem. 2012 PMID:  22948146

Product Documents for GMQ hydrochloride