Catalog Number: 4399
Chemical Name: 3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide
Biological Activity
Allosteric inhibitor of Bcr-Abl tyrosine kinase activity (IC50 = 267 nM); inhibits proliferation and induces apoptosis in Bcr-Abl-expressing cells. Selective for Bcr-Abl over a panel of serine, threonine and tyrosine kinases. Non-ATP-competitive.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Targeting Bcr-Abl by combining allosteric with ATP-binding site inhibitors.
    Zhang et al.
    Nature, 2010;463:501
  2. Allosteric inhibitors of Bcr-abl-dependent cell proliferation.
    Adrián et al.
    Nat.Chem.Biol., 2006;2:95
  3. Inhibitors of Bcr-abl... breaking new ground again.
    Ohren & Sebolt-Leopold et al.
    Nat.Chem.Biol., 2006;2:63
Tocris Small Molecules
Description Application Cat# Citations Images  


View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information

Molarity Calculator
Calculate the mass, volume or concentration required for a solution

The molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol)
An example of a molarity calculation using the molarity calculator:
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?

R&D Systems Guarantee

or select another batch:


Customer Information