GNF 2

Catalog # Availability Size / Price Qty
4399/10
4399/50
GNF 2 | CAS No. 778270-11-4 | Abl Kinase Inhibitors
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Description: Selective allosteric inhibitor of Bcr-Abl tyrosine kinase activity

Chemical Name: 3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide

Purity: ≥98%

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Biological Activity

Allosteric inhibitor of Bcr-Abl tyrosine kinase activity (IC50 = 267 nM); inhibits proliferation and induces apoptosis in Bcr-Abl-expressing cells. Selective for Bcr-Abl over a panel of serine, threonine and tyrosine kinases. Non-ATP-competitive.

Technical Data

M.Wt:
374.32
Formula:
C18H13F3N4O2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
778270-11-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Allosteric inhibitors of Bcr-abl-dependent cell proliferation.
    Adrián et al.
    Nat.Chem.Biol., 2006;2:95
  2. Inhibitors of Bcr-abl... breaking new ground again.
    Ohren & Sebolt-Leopold et al.
    Nat.Chem.Biol., 2006;2:63
  3. Targeting Bcr-Abl by combining allosteric with ATP-binding site inhibitors.
    Zhang et al.
    Nature, 2010;463:501

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