Catalog Number: 4399
Chemical Name: 3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide
Biological Activity
Allosteric inhibitor of Bcr-Abl tyrosine kinase activity (IC50 = 267 nM); inhibits proliferation and induces apoptosis in Bcr-Abl-expressing cells. Selective for Bcr-Abl over a panel of serine, threonine and tyrosine kinases. Non-ATP-competitive.
Technical Data
  • M.Wt:
    374.32
  • Formula:
    C18H13F3N4O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    778270-11-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Targeting Bcr-Abl by combining allosteric with ATP-binding site inhibitors.
    Zhang et al.
    Nature, 2010;463:501
  2. Allosteric inhibitors of Bcr-abl-dependent cell proliferation.
    Adrián et al.
    Nat.Chem.Biol., 2006;2:95
  3. Inhibitors of Bcr-abl... breaking new ground again.
    Ohren & Sebolt-Leopold et al.
    Nat.Chem.Biol., 2006;2:63
Tocris Small Molecules
Description Application Cat# Citations Images  

GNF 5

4908  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Have you used GNF 2?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information