GNF 2

Key Product Details

Product Description

GNF 2 is an allosteric inhibitor of Bcr-Abl tyrosine kinase activity (IC₅₀ = 267 nM); inhibits proliferation and induces apoptosis in Bcr-Abl-expressing cells. Selective for Bcr-Abl over a panel of serine, threonine and tyrosine kinases. Non-ATP-competitive.

Product Specifications for GNF 2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GNF 2

The following data is based on the product molecular weight 374.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.67 mL	13.36 mL	26.72 mL
5 mM	0.53 mL	2.67 mL	5.34 mL
10 mM	0.27 mL	1.34 mL	2.67 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Adrián Allosteric inhibitors of Bcr-abl-dependent cell proliferation. Nat.Chem.Biol. 2006 PMID: 16415863
• Ohren & Sebolt-Leopold Inhibitors of Bcr-abl... breaking new ground again. Nat.Chem.Biol. 2006 PMID: 16421581
• Zhang Targeting Bcr-Abl by combining allosteric with ATP-binding site inhibitors. Nature 2010 PMID: 20072125

Product Documents for GNF 2