GNF 5837

Catalog # Availability Size / Price Qty
4559/10
4559/50
Cat.No. 4559 - GNF 5837 | C28H21F4N5O2 | CAS No. 1033769-28-6
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Description: Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC

Chemical Name: N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

Potent pan-Trk inhibitor. Displays antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively). Exhibits selectivity for Trk receptors over a range of kinases, with some activity at PDGFR and c-Kit (IC50 values are 0.87 and 0.91 μM respectively). Orally bioavailable.

Technical Data

M.Wt:
535.49
Formula:
C28H21F4N5O2
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1033769-28-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Discovery of GNF-5837, a selective TRK inhibitor with efficacy in rodent cancer tumor models.
    Albaugh et al.
    ACS Med.Chem.Lett., 2012;3:140

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Citation for GNF 5837

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