GNF 5837

Tocris Bioscience | Catalog # 4559

Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC
Tocris Bioscience

Key Product Details

Description

Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC
View all Trk Receptor Inhibitors »

Product Description

GNF 5837 is a potent pan-Trk inhibitor. Displays antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively). Exhibits selectivity for Trk receptors over a range of kinases, with some activity at PDGFR and c-Kit (IC50 values are 0.87 and 0.91 μM respectively). Orally bioavailable.

Product Specifications for GNF 5837

Molecular Weight

535.49

Formula

C28H21F4N5O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea

CAS Number

1033769-28-6

PubChem ID

59397065

InChI Key

YYDUWLSETXNJJT-MTJSOVHGSA-N

SMILES

O=C2NC1=CC(NC4=C(C)C=CC(NC(NC5=C(F)C=CC(C(F)(F)F)=C5)=O)=C4)=CC=C1/C2=C/C3=CC=CN3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 53.55 100
Ethanol 5.35 10

Preparing Stock Solutions for GNF 5837

The following data is based on the product molecular weight 535.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.87 mL 9.34 mL 18.67 mL
5 mM 0.37 mL 1.87 mL 3.73 mL
10 mM 0.19 mL 0.93 mL 1.87 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

Product Documents for GNF 5837

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GNF 5837

For research use only

Related Research Areas

Receptor Tyrosine Kinases (RTKs)

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