GNF 7

Key Product Details

Product Description

GNF 7 is a potent Bcr-Abl inhibitor (IC₅₀ values are 61 and 133 nM for T315I and wild-type Bcr-Abl, respectively), inhibiting a range of clinically relevant Bcr-Abl mutants such as T315I, G250E, E255V, F317L and M351T. GNF 7 is also a Ras signaling inhibitor as well as inhibiting Ack1 and germinal center kinase (GCK). GNF 7 induces cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations, and shows growth inhibitory activity in human colon cancer cells. It prolongs survival in a leukemia cell xenotransplantation model in mice and is orally bioavailable.

Product Specifications for GNF 7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GNF 7

The following data is based on the product molecular weight 547.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.65 mL	18.26 mL	36.53 mL
2.5 mM	0.73 mL	3.65 mL	7.31 mL
5 mM	0.37 mL	1.83 mL	3.65 mL
25 mM	0.07 mL	0.37 mL	0.73 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Choi A type-II kinase inhibitor capable of inhibiting the T315I "gatekeeper" mutant of Bcr-Abl. J.Med.Chem 2010 PMID: 20604564
• Nonami Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach. Blood 2015 PMID: 25833960

Product Documents for GNF 7