Ras signaling inhibitor; inhibits Ack1 and germinal center kinase (GCK). Suppresses proliferation, and induces cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations. Prolongs survival in a leukemia cell xenotransplantation model in mice.
Soluble to 50 mM in DMSO
Store at -20°C
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All Tocris products are intended for laboratory research use only.
Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach.
Nonami et al.