GNTI dihydrochloride

  ( 1 citations )    
Product Datasheet
Catalog Number:1282
Chemical Name:5'-Guanidinyl-17-(cyclopropylmethyl)-6,7-dehydro-4,5α-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinan dihydrochloride
Product Details
Citations (1)
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Biological Activity
Highly potent κ opioid receptor antagonist (Ki = 0.18 nM for human cloned κ receptors expressed in CHO cells). Displays 208- and 799-fold selectivity over μ and δ receptors respectively. Reduces feeding behavior in rats with a much higher potency (300-30,000-fold) and a shorter duration of action than nor-binaltorphimine (Cat.No. 0347).
Technical Data
  • M.Wt:
    544.48
  • Formula:
    C27H29N5O3.2HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >96
  • Storage:
    Desiccate at -20°C
  • CAS No:
    351183-88-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for GNTI dihydrochloride include:

1 Citations: Showing 1 - 1

  1. Roles of opioid receptor subtype in the spinal antinociception of selective cyclooxygenase 2 inhibitor.
    Authors: Choi Et al.
    Korean J Pain  2010;23:236

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