Chemical Name: 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
Biological ActivityGolgicide A is a potent, specific and reversible inhibitor of Golgi BFA resistance factor 1 (GBF1), an ArfGEF, that decreases Arf1 activation in vivo. Arrests secretion of soluble and membrane-associated proteins at the endoplasmic reticulum-Golgi intermediate compartment. Causes disassembly and dispersal of the Golgi and trans-Golgi network.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Golgicide A reveals essential roles for GBF1 in Golgi assembly and function.
Saenz et al.
Nature Chem.Biol., 2008;5:157
Citations for Golgicide A
The citations listed below are publications that use Tocris products. Selected citations for Golgicide A include:
2 Citations: Showing 1 - 2
Recruitment of LC3 to damaged Golgi apparatus.
Authors: Gomes-da-Silva Et al.
Cell Death Differ 2019;26:1467
GADD34 function in protein trafficking promotes adaptation to hyperosmotic stress in human corneal cells.
Cell Rep 2017;21(10):2895
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