Chemical Name: 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
Biological ActivityPotent, specific and reversible inhibitor of Golgi BFA resistance factor 1 (GBF1), an ArfGEF, that decreases Arf1 activation in vivo. Arrests secretion of soluble and membrane-associated proteins at the endoplasmic reticulum-Golgi intermediate compartment. Causes disassembly and dispersal of the Golgi and trans-Golgi network.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Golgicide A reveals essential roles for GBF1 in Golgi assembly and function.
Saenz et al.
Nature Chem.Biol., 2008;5:157
Citations for Golgicide A
The citations listed below are publications that use Tocris products. Selected citations for Golgicide A include:
2 Citations: Showing 1 - 2
Recruitment of LC3 to damaged Golgi apparatus.
Authors: Gomes-da-Silva Et al.
Cell Death Differ 2019;26:1467
GADD34 function in protein trafficking promotes adaptation to hyperosmotic stress in human corneal cells.
Cell Rep 2017;21(10):2895
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