Golgicide A

Catalog # Availability Size / Price Qty
3584/10
3584/50
Golgicide A | CAS No. 1139889-93-2 | ARF GTPase Inhibitors
1 Image
Description: Potent, selective and reversible inhibitor of GBF1 ArfGEF

Chemical Name: 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline

Purity: ≥98%

Product Details
Citations (2)
Reviews

Biological Activity

Potent, specific and reversible inhibitor of Golgi BFA resistance factor 1 (GBF1), an ArfGEF, that decreases Arf1 activation in vivo. Arrests secretion of soluble and membrane-associated proteins at the endoplasmic reticulum-Golgi intermediate compartment. Causes disassembly and dispersal of the Golgi and trans-Golgi network.

Technical Data

M.Wt:
284.3
Formula:
C17H14F2N2
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
1139889-93-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Golgicide A reveals essential roles for GBF1 in Golgi assembly and function.
    Saenz et al.
    Nature Chem.Biol., 2008;5:157

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for Golgicide A

The citations listed below are publications that use Tocris products. Selected citations for Golgicide A include:

2 Citations: Showing 1 - 2

  1. Recruitment of LC3 to damaged Golgi apparatus.
    Authors: Gomes-da-Silva Et al.
    Cell Death Differ  2019;26:1467
  2. GADD34 function in protein trafficking promotes adaptation to hyperosmotic stress in human corneal cells.
    Authors: Krokowski
    Cell Rep  2017;21(10):2895

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Golgicide A

There are currently no reviews for this product. Be the first to review Golgicide A and earn rewards!

Have you used Golgicide A?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.