GR 127935 hydrochloride

  ( 6 citations )    
Product Datasheet
Catalog Number:1477
Chemical Name:N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1'-biphenyl-4-carboxamide hydrochloride
Product Details
Citations (6)
Supplemental Products
Reviews
Biological Activity
Potent and selective 5-HT1B/1D receptor antagonist (pKi values are 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptors). Displays > 100-fold selectivity over 5HT1A, 5-HT2A, 5-HT2C receptors and other receptor types. Centrally active following oral administration.
Technical Data
  • M.Wt:
    534.06
  • Formula:
    C29H31N5O3.HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    148642-42-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for GR 127935 hydrochloride include:

6 Citations: Showing 1 - 6
Filter your results:

  1. Lasting neurobehavioral abnormalities in rats after neonatal activation of serotonin 1A and 1B receptors: possible mechanisms for serotonin dysfunction in autistic spectrum disorders.
    Authors: Khatri Et al.
    Psychopharmacology (Berl)  2014;231:1191
  2. Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11.
    Authors: Eriksson Et al.
    J Clin Endocrinol Metab  2013;18:1096
  3. Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres.
    Authors: Baillie Et al.
    Mol Psychiatry  2012;63:362
  4. DHE repression of ATP-mediated sensitization of trigeminal ganglion neurons.
    Authors: Masterson and Durham
    Headache  2010;50:1424
  5. JNK regulates serotonin-mediated proliferation and migration of pulmonary artery smooth muscle cells.
    Authors: Wei Et al.
    Am J Physiol Lung Cell Mol Physiol  2010;298:L863
  6. Antimigraine drug, zolmitriptan, inhibits high-voltage activated calcium currents in a population of acutely dissociated rat trigeminal sensory neurons.
    Authors: Morikawa Et al.
    Mol Pain  2006;2:10

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used GR 127935 hydrochloride?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee