GR 127935 hydrochloride

Key Product Details

Product Description

GR 127935 hydrochloride is a potent and selective 5-HT_1B/1D receptor antagonist (pK_i values are 8.5 for both guinea pig 5-HT_1D and rat 5-HT_1B receptors). Displays > 100-fold selectivity over 5HT_1A, 5-HT_2A, 5-HT_2C receptors and other receptor types. Centrally active following oral administration.

Licensing Information

Sold under license

Product Specifications for GR 127935 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GR 127935 hydrochloride

The following data is based on the product molecular weight 534.06.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

6 5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.87 mL	9.36 mL	18.72 mL
5 mM	0.37 mL	1.87 mL	3.74 mL
10 mM	0.19 mL	0.94 mL	1.87 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

• De Vries Blockade of porcine carotid vascular response to sumatr. by GR 127935, a selective 5-HT_1D receptor antagonist. Br.J.Pharmacol. 1996 PMID: 8733580
• Knobelman Genetic regulation of extracellular serotonin by 5-hydroxytryptamine_1A and 5-hydroxytryptamine_1B autoreceptors in different brain regions of the mouse. J.Pharmacol.Exp.Ther. 2001 PMID: 11504805
• Clitherow Evolution of a novel series of [(N,N-dimethylamino)propyl]- and piperazinylbenzalides as the first selective 5-HT_1D antagonists. J.Med.Chem. 1994 PMID: 8057272

Product Documents for GR 127935 hydrochloride