Potent and selective 5-HT1B/1D
receptor antagonist (pKi
values are 8.5 for both guinea pig 5-HT1D
and rat 5-HT1B
receptors). Displays > 100-fold selectivity over 5HT1A
receptors and other receptor types. Centrally active following oral administration.
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Blockade of porcine carotid vascular response to sumatriptan by GR 127935, a selective 5-HT1D receptor antagonist.
De Vries et al.
Evolution of a novel series of [(N,N-dimethylamino)propyl]- and piperazinylbenzalides as the first selective 5-HT1D antagonists.
Clitherow et al.
Genetic regulation of extracellular serotonin by 5-hydroxytryptamine1A and 5-hydroxytryptamine1B autoreceptors in different brain regions of the mouse.
Knobelman et al.
The citations listed below are publications that use Tocris products. Selected citations for GR 127935 hydrochloride include:
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