A potent, selective, non-peptide, orally active neurokinin NK2
receptor antagonist. Competes for binding of [3
H]GR100679 to hNK2
-transfected CHO cells with a pKi
of 9.5. Inhibits NK2
receptor-mediated contraction of guinea pig trachea with a pA2
of 8.7. Anxiolytic in vivo
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GR 159897, a potent non-peptide antagonist at tachykinin NK2 receptors.
Beresford et al.
The anxiolytic-like activity of GR 159897, a non-peptide NK2 receptor antagonist, in rodent and primate models of anxiety.
Walsh et al.
GR 159897 and related analogues as highly potent, orally active non-peptide neurokinin NK2 receptor antagonists.
Cooper et al.
The citations listed below are publications that use Tocris products. Selected citations for GR 159897 include:
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