GR 159897

Key Product Details

Product Description

GR 159897 is a potent, selective, non-peptide, orally active neurokinin NK₂ receptor antagonist. Competes for binding of [³H]GR100679 to hNK₂-transfected CHO cells with a pK_i of 9.5. Inhibits NK₂ receptor-mediated contraction of guinea pig trachea with a pA₂ of 8.7. Anxiolytic in vivo.

Licensing Information

Sold with the permission of GlaxoSmithKline

Product Specifications for GR 159897

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GR 159897

The following data is based on the product molecular weight 414.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.82 mL	24.12 mL	48.25 mL
2.5 mM	0.96 mL	4.82 mL	9.65 mL
5 mM	0.48 mL	2.41 mL	4.82 mL
25 mM	0.10 mL	0.48 mL	0.96 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Walsh The anxiolytic-like activity of GR 159897, a non-peptide NK₂ receptor antagonist, in rodent and primate models of anxiety. Psychopharmacology 1995 PMID: 8545524
• Cooper GR 159897 and related analogues as highly potent, orally active non-peptide neurokinin NK₂ receptor antagonists. Bioorg.Med.Chem.Lett.
• Beresford GR 159897, a potent non-peptide antagonist at tachykinin NK₂ receptors. Eur.J.Pharmacol. 1995 PMID: 7713168

Product Documents for GR 159897