GR 73632

Name: GR 73632
Brand: Tocris Bioscience
SKU: 1669
Price: 492 USD
Availability: InStock

Tocris Bioscience | Catalog # 1669

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Citations (33)

Product Documents

Potent and selective NK1 agonist

Product Description
Licensing Information
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent and selective NK1 agonist

View all NK1 Receptor Agonists »

Product Description

GR 73632 is a potent and selective tachykinin NK₁ receptor agonist (EC₅₀ = 2 nM in guinea pig vas deferens). Active in vivo. Intrathecal administration of GR 73632 in mice increases itch behavior.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Product Specifications for GR 73632

Molecular Weight

766.01

Formula

C₄₀H₅₉N₇O₆S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

133156-06-6

PubChem ID

119599

InChI Key

HQKPTSSZOJLFBZ-LJADHVKFSA-N

SMILES

[H]N([C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(=O)CCCCN

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 33 publications citing the usage of this product.

Sheahan The neurokinin-1 receptor is expressed with gastrin-releasing peptide receptor in spinal interneurons and modulates itch. J.Neurosci. 2021 PMID: 33051347
Meini GR 73,632 and [glu(OBzl)11]substance P are selective agonists for the septide-sensitive tachykinin NK₁ receptor in the rat urinary bladder. Neuropeptides 1995 PMID: 7538205
Sakurada Spinal actions of GR73632, a novel tachykinin NK₁ receptor agonist. Peptides 1999 PMID: 10422886
Hall and Morton Novel ligands confirm NK-1 receptor-mediated modulation of neurotransmission in the guinea pig vas deferens preparation. Ann.N.Y.Acad.Sci. 1991 PMID: 1719888

Product Documents for GR 73632

Certificate of Analysis

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Product Specific Notices for GR 73632

For research use only

Citations for GR 73632

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