Biological ActivityPotent and selective tachykinin NK1 receptor agonist (EC50 = 2 nM in guinea pig vas deferens). Active in vivo.
(Modifications: Phe-1 = delta-Aminovaleryl-Phe, Leu-4 = (methyl)Leu, Met-5 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Novel ligands confirm NK-1 receptor-mediated modulation of neurotransmission in the guinea pig vas deferens preparation.
Hall and Morton
GR 73,632 and [glu(OBzl)11]substance P are selective agonists for the septide-sensitive tachykinin NK1 receptor in the rat urinary bladder.
Meini et al.
Spinal actions of GR73632, a novel tachykinin NK1 receptor agonist.
Sakurada et al.
Citations for GR 73632
The citations listed below are publications that use Tocris products. Selected citations for GR 73632 include:
5 Citations: Showing 1 - 5
Direct actions of kisspeptins on GnRH neurons permit attainment of fertility but are insufficient to fully preserve gonadotropic axis activity.
Authors: León Et al.
Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity.
Authors: León Et al.
The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction.
Authors: Navarro Et al.
Mol Psychiatry 2015;156:627
Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats.
Authors: Ruiz-Pino Et al.
TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis.
Authors: Liu Et al.
FASEB J 2013;27:3549
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