Catalog Number: 1669
Biological Activity
Potent and selective tachykinin NK1 receptor agonist (EC50 = 2 nM in guinea pig vas deferens). Active in vivo.
Technical Data
  • M.Wt:
    766.01
  • Formula:
    C40H59N7O6S
  • Sequence:
    FFPLM

    (Modifications: Phe-1 = delta-Aminovaleryl-Phe, Leu-4 = (methyl)Leu, Met-5 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    133156-06-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline
Background References
  1. Novel ligands confirm NK-1 receptor-mediated modulation of neurotransmission in the guinea pig vas deferens preparation.
    Hall and Morton
    Ann.N.Y.Acad.Sci., 1991;632:404
  2. GR 73,632 and [glu(OBzl)11]substance P are selective agonists for the septide-sensitive tachykinin NK1 receptor in the rat urinary bladder.
    Meini et al.
    Neuropeptides, 1995;28:99
  3. Spinal actions of GR73632, a novel tachykinin NK1 receptor agonist.
    Sakurada et al.
    Peptides, 1999;20:301
Citations:

The citations listed below are publications that use Tocris products. Selected citations for GR 73632 include:

5 Citations: Showing 1 - 5
Filter your results:

  1. Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity.
    Authors: León Et al.
    Endocrinology 2016;6:19206
  2. Direct actions of kisspeptins on GnRH neurons permit attainment of fertility but are insufficient to fully preserve gonadotropic axis activity.
    Authors: León Et al.
    Sci.Rep. 2016;6:19206
  3. The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction.
    Authors: Navarro Et al.
    Mol Psychiatry 2015;156:627
  4. Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats.
    Authors: Ruiz-Pino Et al.
    Endocrinology 2015;156:576
  5. TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis.
    Authors: Liu Et al.
    FASEB J 2013;27:3549

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