Grifolic acid

Catalog # Availability Size / Price Qty
Grifolic acid | CAS No. 80557-12-6 | Free Fatty Acid Receptor Agonists
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Description: Selective partial FFA4 (GPR120) agonist

Chemical Name: 2,4-Dihydroxy-6-methyl-3-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]-benzoic acid

Purity: ≥98%

Product Details
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Biological Activity

Grifolic acid is a selective partial FFA4 (GPR120) agonist. Induces ERK and [Ca2+]i responses in cells expressing GPR120, but not those expressing GPR40.

Technical Data

Soluble to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Arachidonic acid triggers [Ca2+]i increases in rat round spermatids by a likely GPR activation, ERK signalling and ER/acidic compartments Ca2+ release
    J Paillamanq, A Sanchez-Tu, EM Carmona, CL Treviño, C Sandoval, F Nualart, N Osses, JG Reyes
    PLoS ONE, 2017;12(2):e0172128.
  2. Novel selective ligands for free fatty acid receptors GPR120 and GPR40.
    Hara et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 2009;380:247
  3. Structure-activity relationships of GPR120 agonists based on a docking simulation.
    Sun et al.
    Mol.Pharmacol., 2010;78:804

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