Chemical Name: 5-Amino-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]benzamide
Biological ActivityGRL 0617 is a coronavirus papain-like protease (Plpro) inhibitor (IC50 values are 0.6 and 0.8 μM for SARS-COV and SARS-CoV-2 PLpro, respectively). Inhibits deubiquitination activity of SARS-CoV PLpro. Displays no inhibition of human deubiquitinating enzymes. Improves cell viability following SARS-CoV infection. Inhibits SARS-CoV-2 viral replication and induces antiviral immune signaling pathways following SARS-CoV-2 infection in CaCo-2 cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication.
Ratia et al.
Characterization and noncovalent inhibition of the deubiquitinase and deISGylase activity of SARS-CoV-2 papain-Like protease.
Freitas et al.
ACS Infect.Dis., 2020;
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.
Shin et al.
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