Positive allosteric modulator of GABAB
receptor function. Potentiates the effects of GABA on [35
S binding at recombinant and native GABAB
values are 2.1 and 3.1μ
M respectively). Decreases cocaine self-administration, blocks the rewarding properties of nicotine and produces anxiolytic-like activity without the side effects associated with baclofen or benzodiazepines.
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All Tocris products are intended for laboratory research use only.
N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of γ-aminobutyric acidB receptor function.
Urwyler et al.
Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine: anxiolytic-like activity without side effects associated with baclofen or benzo
Cryan et al.
GABAB receptor-positive modulation-induced blockade of the rewarding effects of nicotine is associated with a reduction in nucleus accumbens ΔFosB accumulation.
Mombereau et al.
The citations listed below are publications that use Tocris products. Selected citations for GS 39783 include:
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