GS 39783

Catalog # Availability Size / Price Qty
2001/10
2001/50
GS 39783 | CAS No. 39069-52-8 | GABA-B Receptor Modulators
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Description: Positive allosteric modulator of GABAB receptors

Chemical Name: N,N'-Dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediamine

Purity: ≥98%

Product Details
Citations (2)
Supplemental Products
Reviews

Biological Activity

Positive allosteric modulator of GABAB receptor function. Potentiates the effects of GABA on [35S]GTPγS binding at recombinant and native GABAB receptors (EC50 values are 2.1 and 3.1μM respectively). Decreases cocaine self-administration, blocks the rewarding properties of nicotine and produces anxiolytic-like activity without the side effects associated with baclofen or benzodiazepines.

Technical Data

M.Wt:
337.44
Formula:
C15H23N5O2S
Solubility:
Soluble to 5 mM in ethanol and to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
39069-52-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for GS 39783

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