Chemical Name: N,N'-Dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediamine
Biological ActivityPositive allosteric modulator of GABAB receptor function. Potentiates the effects of GABA on [35S]GTPγS binding at recombinant and native GABAB receptors (EC50 values are 2.1 and 3.1μM respectively). Decreases cocaine self-administration, blocks the rewarding properties of nicotine and produces anxiolytic-like activity without the side effects associated with baclofen or benzodiazepines.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of γ-aminobutyric acidB receptor function.
Urwyler et al.
GABAB receptor-positive modulation-induced blockade of the rewarding effects of nicotine is associated with a reduction in nucleus accumbens ΔFosB accumulation.
Mombereau et al.
Elucidation of the neural circuits activated by a GABAB receptor positive modulator: Relevance to anxiety.
Pizzo et al.
Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine: anxiolytic-like activity without side effects associated with bac. or benzo
Cryan et al.
Citations for GS 39783
The citations listed below are publications that use Tocris products. Selected citations for GS 39783 include:
2 Citations: Showing 1 - 2
GABAB receptor upregulates fragile X mental retardation protein expression in neurons.
Authors: Zhang Et al.
Sci Rep 2015;5:10468
Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome.
Authors: Pacey Et al.
Sci Rep 2011;338:897
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