Smoothened (Smo) receptor agonist (EC50
= 1.2 μ
M). Does not recognize the classic cyclopamine
(Cat. No. 1623) binding site. Does not promote Smo translocation to the primary cilium; is strongly potentiated by forskolin and cholera toxin. Promotes differentiation of multipotent mesenchymal progenitor cells into osteoblasts.
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All Tocris products are intended for laboratory research use only.
Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened.
Gorojankina et al.