Catalog Number: 4026
Chemical Name: 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione
Biological Activity
Potent inhibitor of PI 3-kinase α (PI3Kα) (IC50 = 2 nM). Inhibits proliferation in BT474 cells and attenuates MAPK signaling.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline
Background References
  1. Phosphatidylinositol-3-kinase as a therapeutic target in melanoma.
    Saadia et al.
    Clin.Cancer Res., 2009;15:3029
  2. Discovery of GSK2126458, a highly potent inhibitor of PI3K and the mammalian target of rapamycin.
    Knight et al.
    ACS Med.Chem.Lett., 2010;1:39
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