GSK 1059615

Catalog #: 4026 Datasheet / COA / SDS

Discontinued Product

4026 has been discontinued.
View all PI 3-Kinase Inhibitors products.
GSK 1059615 | CAS No. 958852-01-2 | PI 3-Kinase Inhibitors
1 Image
Description: Potent PI 3-kinase inhibitor

Chemical Name: 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione

Purity: ≥98%

Product Details

Biological Activity

GSK 1059615 is a potent inhibitor of PI 3-kinase α (PI3Kα) (IC50 = 2 nM). Inhibits proliferation in BT474 cells and attenuates MAPK signaling.

Technical Data

Soluble to 10 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline

Background References

  1. Phosphatidylinositol-3-kinase as a therapeutic target in melanoma.
    Saadia et al.
    Clin.Cancer Res., 2009;15:3029
  2. Discovery of GSK2126458, a highly potent inhibitor of PI3K and the mammalian target of rapamycin.
    Knight et al.
    ACS Med.Chem.Lett., 2010;1:39

Product Datasheets

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