Chemical Name: 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione
Biological ActivityPotent inhibitor of PI 3-kinase α (PI3Kα) (IC50 = 2 nM). Inhibits proliferation in BT474 cells and attenuates MAPK signaling.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Phosphatidylinositol-3-kinase as a therapeutic target in melanoma.
Saadia et al.
Clin.Cancer Res., 2009;15:3029
Discovery of GSK2126458, a highly potent inhibitor of PI3K and the mammalian target of rapamycin.
Knight et al.
ACS Med.Chem.Lett., 2010;1:39
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