GSK 1059615

Key Product Details

Product Description

GSK 1059615 is a potent inhibitor of PI 3-kinase α (PI3Kα) (IC₅₀ = 2 nM). Inhibits proliferation in BT474 cells and attenuates MAPK signaling.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Product Specifications for GSK 1059615

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GSK 1059615

The following data is based on the product molecular weight 333.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.00 mL	149.99 mL	299.98 mL
0.5 mM	6.00 mL	30.00 mL	60.00 mL
1 mM	3.00 mL	15.00 mL	30.00 mL
5 mM	0.60 mL	3.00 mL	6.00 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Knight Discovery of GSK2126458, a highly potent inhibitor of PI3K and the mammalian target of rapamycin. ACS Med.Chem.Lett.
• Saadia Phosphatidylinositol-3-kinase as a therapeutic target in melanoma. Clin.Cancer Res. 2009 PMID: 19383818

Product Documents for GSK 1059615