GSK 1059615

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4026/10
4026/50
GSK 1059615 | CAS No. 958852-01-2 | PI 3-Kinase Inhibitors
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Description: Potent PI 3-kinase inhibitor

Chemical Name: 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione

Purity: ≥98%

Product Details
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Biological Activity

Potent inhibitor of PI 3-kinase α (PI3Kα) (IC50 = 2 nM). Inhibits proliferation in BT474 cells and attenuates MAPK signaling.

Technical Data

M.Wt:
333.36
Formula:
C18H11N3O2S
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
958852-01-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline

Background References

  1. Phosphatidylinositol-3-kinase as a therapeutic target in melanoma.
    Saadia et al.
    Clin.Cancer Res., 2009;15:3029
  2. Discovery of GSK2126458, a highly potent inhibitor of PI3K and the mammalian target of rapamycin.
    Knight et al.
    ACS Med.Chem.Lett., 2010;1:39

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