Potent inhibitor of PI 3-kinase α
= 2 nM). Inhibits proliferation in BT474 cells and attenuates MAPK signaling.
Soluble to 10 mM in DMSO
Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold for research purposes under agreement from GlaxoSmithKline
Phosphatidylinositol-3-kinase as a therapeutic target in melanoma.
Saadia et al.
Clin.Cancer Res., 2009;15:3029
Discovery of GSK2126458, a highly potent inhibitor of PI3K and the mammalian target of rapamycin.
Knight et al.
ACS Med.Chem.Lett., 2010;1:39