GSK 2239633A New
Chemical Name: N-[[3-[[3-[[(5-Chloro-2-thienyl)sulfonyl]amino]-4-methoxy-1H-indazol-1-yl]methyl]phenyl]methyl]-2-hydroxy-2-methylpropanamide
Biological ActivityPotent CCR4 antagonist (pIC50 = 7.83 in a 35S-GTPγS competition assay). Inhibits thymus activation-regulated chemokine (TARC) -induced F-actin polymerization in human whole blood.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Lead optimisation of the N1 substituent of a novel series of indazole arylsulfonamides as CCR4 antagonists and identification of a candidate for clinical investigation.
Procopiou et al.
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