GSK 2239633A

Key Product Details

Product Description

GSK 2239633A is a potent CCR4 antagonist (pIC₅₀ = 7.83 in a ³⁵S-GTPγS competition assay). Inhibits thymus activation-regulated chemokine (TARC) -induced F-actin polymerization in human whole blood.

Product Specifications for GSK 2239633A

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GSK 2239633A

The following data is based on the product molecular weight 549.06.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.82 mL	9.11 mL	18.21 mL
5 mM	0.36 mL	1.82 mL	3.64 mL
10 mM	0.18 mL	0.91 mL	1.82 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Procopiou Lead optimisation of the N1 substituent of a novel series of indazole arylsulfonamides as CCR4 antagonists and identification of a candidate for clinical investigation. Bioorg.Med.Chem.Lett. 2012 PMID: 22437117

Product Documents for GSK 2239633A