GSK 2795039

Tocris Bioscience | Catalog # 6848

NADPH oxidase 2 (NOX2) inhibitor
Tocris Bioscience

Key Product Details

Description

NADPH oxidase 2 (NOX2) inhibitor
View all NADPH Oxidase Inhibitors »

Product Description

GSK 2795039 is a NADPH oxidase 2 (NOX2) inhibitor (pIC50 value is 5.5 to 6.5, depending on assay performed), which displays selectivity for NOX2 other NOX isoforms, xanthine oxidase and eNOS. GSK 2795039 inhibits reactive oxygen species (ROS) in cellular assays, and displays efficacy in rodent models of paw inflammation and acute pancreatitis.

Product Specifications for GSK 2795039

Molecular Weight

450.56

Formula

C23H26N6O2S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[3-(2,3-Dihydro-1-methyl-1H-indol-6-yl)-1-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-methyl-1H-pyrazole-3-sulfonamide

CAS Number

1415925-18-6

PubChem ID

71090129

InChI Key

FMWVTCZKCXPKFW-UHFFFAOYSA-N

SMILES

CC(N1C=C(C2=CC=C3CCN(C3=C2)C)C4=C(C=CN=C14)NS(=O)(C5=NN(C=C5)C)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.06 100

Preparing Stock Solutions for GSK 2795039

The following data is based on the product molecular weight 450.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.10 mL 22.19 mL
5 mM 0.44 mL 2.22 mL 4.44 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

Product Documents for GSK 2795039

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GSK 2795039

For research use only

Related Research Areas

Oxidases and Oxygenases
Redox Enzymes

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