GSK 3787
Chemical Name: 4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide
Purity: ≥99%
Biological Activity
GSK 3787 is a potent and selective peroxisome proliferator-activated receptor δ (PPARδ) antagonist (pIC50 = 6.6). Displays no measurable affinity for PPARα or PPARγ in vitro (pIC50< 5).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification and characterization of 4-chloro-N(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist.
Shearer et al.
J.Med.Chem., 2010;53:1857 -
Cellular and pharmacological selectivity of the peroxisone proliferator-activated receptor-β/δ antagonist GSK3787.
Palkar et al.
Mol.Pharmacol., 2010;78:419
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Citation for GSK 3787
The citations listed below are publications that use Tocris products. Selected citations for GSK 3787 include:
1 Citation: Showing 1 - 1
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PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells.
Authors: Samokhvalov Et al.
Cell Cycle 2015;232:44105
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