Catalog Number: 3663
Alternate Names: SR 6452
Chemical Name: 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
Biological Activity
Selective Rev-Erbα agonist (EC50 = 250 nM). Enhances recruitment of nuclear receptor co-repressor (NCoR) peptide to Rev-Erbα; causes acute suppression of Bmal1 gene transcription. Induces phase shifts in the circadian clock.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB.
    Kojetin et al.
    ACS Chem. Biol., 2011;6:131
  2. Ligand modulation of REV-ERBα function resets the peripheral circadian clock in a phasic manner.
    Meng et al.
    J.Cell Science, 2008;121:3629
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