= 250 nM). Enhances recruitment of nuclear receptor co-repressor (NCoR) peptide to Rev-Erbα
; causes acute suppression of Bmal1
gene transcription. Induces phase shifts in the circadian clock.
Soluble to 25 mM in DMSO
Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB.
Kojetin et al.
ACS Chem. Biol., 2011;6:131
Ligand modulation of REV-ERBα function resets the peripheral circadian clock in a phasic manner.
Meng et al.
J.Cell Science, 2008;121:3629