GSK 4112

Catalog # Availability Size / Price Qty
3663/10
3663/50
GSK 4112 | CAS No. 1216744-19-2 | Nuclear Receptor Agonists
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Description: Selective Rev-Erbα agonist
Alternative Names: SR 6452

Chemical Name: 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Selective Rev-Erbα agonist (EC50 = 250 nM). Enhances recruitment of nuclear receptor co-repressor (NCoR) peptide to Rev-Erbα; causes acute suppression of Bmal1 gene transcription. Induces phase shifts in the circadian clock.

Technical Data

M.Wt:
396.89
Formula:
C18H21ClN2O4S
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1216744-19-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB.
    Kojetin et al.
    ACS Chem.Biol., 2011;6:131
  2. Ligand modulation of REV-ERBα function resets the peripheral circadian clock in a phasic manner.
    Meng et al.
    J.Cell Science, 2008;121:3629

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Citation for GSK 4112

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