Chemical Name: 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
Biological ActivityGSK 4112 is a selective Rev-Erbα agonist (EC50 = 250 nM). Enhances recruitment of nuclear receptor co-repressor (NCoR) peptide to Rev-Erbα; causes acute suppression of Bmal1 gene transcription. Induces phase shifts in the circadian clock.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB.
Kojetin et al.
ACS Chem.Biol., 2011;6:131
Ligand modulation of REV-ERBα function resets the peripheral circadian clock in a phasic manner.
Meng et al.
J.Cell Science, 2008;121:3629
Citation for GSK 4112
The citations listed below are publications that use Tocris products. Selected citations for GSK 4112 include:
1 Citation: Showing 1 - 1
NR1D1 ameliorates Mycobacterium tuberculosis clearance through regulation of autophagy.
Authors: Chandra Et al.
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