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GSK 429286

3726 2 Citations Datasheet / COA / SDS
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GSK 429286 | CAS No. 864082-47-3 | Rho-kinase Inhibitors
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Description: Selective Rho-kinase (ROCK) inhibitor
Alternative Names: GSK429286A

Chemical Name: 4-[4-(Trifluoromethyl)phenyl]-N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamide

Purity: ≥97%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Selective Rho-kinase inhibitor (IC50 values are 14, 780 and 1940 nM for ROCK1, RSK and p70S6K respectively). Reverses adrenalin-induced contraction of the rat aortic ring (IC50 = 190 nM) and causes a dose-dependent decrease in mean arterial blood pressure in spontaneous hypertensive rats. Orally active.

Technical Data

M.Wt:
432.37
Formula:
C21H16F4N4O2
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥97%
Storage:
Store at +4°C
CAS No:
864082-47-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline

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Citations for GSK 429286

The citations listed below are publications that use Tocris products. Selected citations for GSK 429286 include:

2 Citations: Showing 1 - 2

  1. RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6.
    Authors: Durkin Et al.
    Dev Cell  2017;41:315
  2. Neural Precursor-Derived Pleiotrophin Mediates Subventricular Zone Invasion by Glioma.
    Authors: Qin Et al.
    Cell  2017;170:845

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